CCKBR 抗体 (Extracellular, N-Term)
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Quick Overview for CCKBR 抗体 (Extracellular, N-Term) (ABIN7043059)
抗原
See all CCKBR 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 39-53, Extracellular, N-Term
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原理
- A Rabbit Polyclonal Antibody to the Cholecystokinin B Receptor
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- human - 13,Rat - 14,15 amino acid residues identical
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产品特性
- Anti-CCKBR (extracellular) Antibody (ABIN7043059, ABIN7044183 and ABIN7044184) is a highly specific antibody directed against an epitope of the mouse cholecystokinin B receptor. The antibody can be used in western blot, indirect flow cytometry, and immunohistochemistry applications. It has been designed to recognize CCKBR from mouse, rat, and human samples.
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纯化方法
- Affinity purified on immobilized antigen.
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免疫原
- CETPRIRGTGTRELE, corresponding to amino acid residues 39-53 of mouse Gastrin/cholecystokinin type B receptor
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亚型
- IgG
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anti-Cholecystokinin B Receptor (CCKBR) (Internal Region) antibody
Verified CCKBR 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (AA 301-400) antibodyCCKBR 适用: 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (N-Term) antibodyCCKBR 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (C-Term) antibodyCCKBR 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (AA 243-333) antibodyCCKBR 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) antibodyCCKBR 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (Extracellular Domain) antibodyCCKBR 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (Cytoplasmic Domain) antibodyCCKBR 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (N-Term) antibodyCCKBR 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cholecystokinin B Receptor (CCKBR) (N-Term) antibodyCCKBR 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB: 1:200
FC: 5 μg per reaction
ICC: The optimal concentration should be determined by the user
IHC: 1:100-1:200
IP: The optimal concentration should be determined by the user
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说明
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Cited Application: IFC
Negative Control: (ABIN7235114)
Blocking Peptide: (ABIN7235114)
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.
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浓度
- 0.8 mg/mL
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缓冲液
- PBS pH 7.4, 1 % BSA with 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C
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- CCKBR (Cholecystokinin B Receptor (CCKBR))
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别名
- CCKBR
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背景
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Synonyms: Cholecystokinin B receptor, Gastrin receptor, CCK2R, GASR
Description: Cholecystokinin B receptor (CCKBR), also known as the Gastrin receptor and CCKR2, belongs to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily, and is one of the two receptors that mediates the effects of the cholecystokinin (CCK) and gastrin peptides1,2.CCK and gastrin are related linear peptides that occur in different forms but share the last five C-terminal amino acid residues. CCK regulates several nutritional-related activities such as stimulation of pancreatic exocrine secretion or the regulation of intestinal transit, while gastrin's main function is the stimulation of gastric acid secretion1,2.Both CCKBR and the other CCK receptor (CCKAR or CCK1R) are coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), and intracellular Ca2+mobilization.CCKBR was originally identified in the brain (and hence its name, type B for Brain) where it is widely distributed, notably in the cerebral cortex and striatum. In the periphery, CCKBR is most notably expressed in acid secreting cells in the mucosa of the stomach. The tissue distribution of CCKBR corresponds to the proposed roles of the receptor which include anxiety, pain perception, gastric acid secretion, and growth and differentiation of the gastric mucosa1,2.
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基因ID
- 12426
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NCBI登录号
- NM_176875
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UniProt
- P56481
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途径
- Positive Regulation of Peptide Hormone Secretion, Feeding Behaviour
抗原
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