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CDK6 抗体 (AA 21-110)

Name: CDK6 抗体 (AA 21-110)
SKU: ABIN670236
Availability: OutOfStock

This anti-CDK6 antibody is a 兔多克隆 antibody detecting CDK6 in WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 和 FACS. Suitable for 人, 小鼠和大鼠. This Primary Antibody has been cited in 5+ publications.

Formalin-fixed and paraffin embedded human breast carcinoma labeled with Anti-CDK6 Polyclonal Antibody (ABIN670236), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining (CDK6 抗体 (AA 21-110))

IHC

A431 lysates probed with CDK6 Polyclonal Antibody, Unconjugated at 1:500 dilution and 4˚C overnight incubation. (CDK6 抗体 (AA 21-110))

2 images

(5 references)

产品编号 ABIN670236

发货至: 中国

Quick Overview for CDK6 抗体 (AA 21-110) (ABIN670236)

抗原

See all CDK6 抗体

CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This CDK6 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)

Discover our top product CDK6 Primary Antibody

抗原表位
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AA 21-110

交叉反应

人, 小鼠, 大鼠

预测反应

Dog,Cow,Horse

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human CDK6

亚型

IgG
anti-Cyclin-Dependent Kinase 6 (CDK6) (AA 3-99) antibody
CDK6 适用: 人 WB, IF, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 8H4 unconjugated

anti-Cyclin-Dependent Kinase 6 (CDK6) antibody
KO Validated CDK6 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 6 (CDK6) (AA 280-325) antibody
CDK6 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 6 (CDK6) antibody
CDK6 适用: 人, 大鼠 WB, IF, IHC (p), EIA 宿主: 小鼠 Monoclonal 8H4 unconjugated

anti-Cyclin-Dependent Kinase 6 (CDK6) antibody
CDK6 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Monoclonal 4F7 unconjugated

anti-Cyclin-Dependent Kinase 6 (CDK6) (pTyr24) antibody
CDK6 适用: 人 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 6 (CDK6) (N-Term) antibody
CDK6 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 6 (CDK6) (AA 102-326) antibody
CDK6 适用: 人 IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Cyclin-Dependent Kinase 6 (CDK6) antibody
CDK6 适用: 人 WB, ELISA, IP 宿主: 兔 Monoclonal 8G3 unconjugated Recombinant Antibody

anti-Cyclin-Dependent Kinase 6 (CDK6) (AA 1-326) antibody
CDK6 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
He, Zheng, Zhang, Gan, Zhou, Liang, Wu, Ge, Deng, Xu: "Long non-coding RNA AK058003, as a precursor of miR-15a, interacts with HuR to inhibit the expression of γ-synuclein in hepatocellular carcinoma cells." in: Oncotarget, Vol. 8, Issue 6, pp. 9451-9465, (2016) (PubMed).

Yang, Wang, Hui, Li, Jiang: "SOX 1, contrary to SOX 2, suppresses proliferation, migration, and invasion in human laryngeal squamous cell carcinoma by inhibiting the Wnt/?-catenin pathway." in: Tumour biology, (2015) (PubMed).

Hu, Fan, Lv, Zhou, Yang, Zheng, Cao: "5-Aminolevulinic acid-mediated sonodynamic therapy induces anti-tumor effects in malignant melanoma via p53-miR-34a-Sirt1 axis." in: Journal of dermatological science, Vol. 79, Issue 2, pp. 155-62, (2015) (PubMed).

Zhang, Wang, Li, Huo, Mu, Liu, Han: "miR-145 downregulates the expression of cyclin-dependent kinase 6 in human cervical carcinoma cells." in: Experimental and therapeutic medicine, Vol. 8, Issue 2, pp. 591-594, (2014) (PubMed).

Zhang, Zhu, Zuo, Luo, Mao, Ye, Li, Liu, Wei, Ye, Chen, Wang: "The ClC-3 chloride channel protein is a downstream target of cyclin D1 in nasopharyngeal carcinoma cells." in: The international journal of biochemistry & cell biology, Vol. 45, Issue 3, pp. 672-83, (2013) (PubMed).
抗原

CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

别名

CDK6

背景

Synonyms: MCPH12, PLSTIRE, Cyclin-dependent kinase 6, Cell division protein kinase 6, Serine/threonine-protein kinase PLSTIRE, CDK6, CDKN6
Background: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation, promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation, prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).

基因ID

1021

UniProt

Q00534

途径

Cell Division Cycle, Mitotic G1-G1/S Phases