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CDK6 抗体 (N-Term)

Name: CDK6 抗体 (N-Term)
SKU: ABIN6260716
Availability: OutOfStock

CDK6 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

Western blot analysis of Hela whole cell lysates, using CDK6 Antibody. (CDK6 抗体 (N-Term))

ABIN6276713 at 1/100 staining Human breast cancer tissue by IHC-P. (CDK6 抗体 (N-Term))

IHC

2 images

(1 reference)

产品编号 ABIN6260716

发货至: 中国

Datasheet as PDF

抗原 See all CDK6 抗体

CDK6 (Cyclin-Dependent Kinase 6 (CDK6))
抗原表位
22

21

14

11

6

4

3

2

2

2

1

1

1

1

1

1

1

1
N-Term
适用
127

48

25

4

4

4

4

2

2

2

1
人, 小鼠, 大鼠
宿主
110

17
兔
Compatible Secondaries
克隆类型
99

28
多克隆
标记
68

7

5

5

4

4

4

4

4

4

2

2

2

2

2

2

2

2

2
This CDK6 antibody is un-conjugated
应用范围
76

37

29

27

27

24

23

13

8

5

2

2

2

2

1
Western Blotting (WB), Immunohistochemistry (IHC), ELISA

特异性

CDK6 Antibody detects endogenous levels of total CDK6.

预测反应

Pig,Zebrafish,Bovine,Horse,Rabbit,Dog,Chicken

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human CDK6, corresponding to a region within N-terminal amino acids.

亚型

IgG

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anti-Cyclin-Dependent Kinase 6 (CDK6) (pTyr24) antibody
CDK6 适用: 人 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
Li, Wang, Yu, Wu, Hu, Wang, Ye: "miR-3619-5p inhibits prostate cancer cell growth by activating CDKN1A expression." in: Oncology reports, Vol. 37, Issue 1, pp. 241-248, (2017) (PubMed).
抗原

CDK6 (Cyclin-Dependent Kinase 6 (CDK6))

别名

CDK6 (CDK6 产品)

别名

CDK6 antibody, PLSTIRE antibody, 5830411I20 antibody, AI504062 antibody, Crk2 antibody, cyclin dependent kinase 6 antibody, cyclin-dependent kinase 6 antibody, CDK6 antibody, Cdk6 antibody

背景

Description: Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation, promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation, prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).
Gene: CDK6

分子量

36kDa

基因ID

1021

UniProt

Q00534

途径

Cell Division Cycle, Mitotic G1-G1/S Phases