MERTK 抗体 (AA 501-600) (HRP)
Quick Overview for MERTK 抗体 (AA 501-600) (HRP) (ABIN669975)
抗原
See all MERTK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 501-600
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交叉反应
- 小鼠
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预测反应
- Human,Rat
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human of human MERTK
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亚型
- IgG
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anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 587-858) antibody
MERTK 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 501-600) antibodyMERTK 适用: 小鼠 ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) antibodyMERTK 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 55-148) antibodyMERTK 适用: 人 IHC, IHC (f) 宿主: 小鼠 Monoclonal MERTK-3015 unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 402-416), (Extracellular) antibodyMERTK 适用: 小鼠 WB, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 840-999) antibodyMERTK 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 21-120) antibodyMERTK 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D2 unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) antibodyMERTK 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB17701 unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (AA 946-980), (C-Term) antibodyMERTK 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB50416 unconjugated
anti-C-Mer Proto-Oncogene Tyrosine Kinase (MERTK) (Extracellular Domain) antibodyMERTK 适用: 人 WB 宿主: 小鼠 Monoclonal A311F9G3 unconjugated
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应用备注
- IHC-P 1:200-400
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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注意事项
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))
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别名
- MERTK
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背景
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Synonyms: MER, RP38, c-Eyk, c-mer, Tyro12, Tyrosine-protein kinase Mer, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, MERTK
Background: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
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基因ID
- 10461
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UniProt
- Q12866
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途径
- RTK signaling
抗原
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