SYN1 抗体 (pSer9)
Quick Overview for SYN1 抗体 (pSer9) (ABIN6658201)
抗原
See all SYN1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer9
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Supplier Product No.
- 612-401-c93
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Supplier
- Rockland
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原理
- Synapsin I phospho S9 Antibody
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交叉反应 (详细)
- The antibody detects the phosphorylated S9 amino acid.
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纯化方法
- Anti-Synapsin I pS9 antibody is directed against rat Synapsin I.
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免疫原
- Anti-Synapsin I pS9 Antibody was produced in rabbit by repeated immunizations with synthetic phospho-peptide corresponding to amino acid residues surrounding Ser9 of Synapsin I.
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亚型
- IgG
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应用备注
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Immunohistochemistry_Dilution: 1:500
Western_Blot_Dilution: 1:1000
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说明
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Anti-Synapsin I pS9 (Rabbit) antibody is tested for use in Western Blotting and ICC. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 78 kDa in size corresponding to synapsin I doublet protein phosphorylated at Ser9 in the appropriate cell lysate or extract. This antibody also weakly labels the approximately 55 kDa synapsin II protein which has a similar phosphorylation site to that of Ser9 on synapsin I. Researchers should determine optimal titers for applications that are not stated below.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5
Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
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有效期
- 12 months
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- SYN1 (Synapsin I (SYN1))
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别名
- Synapsin I
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背景
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Synonyms: Synapsin I, SYN1
Background: Synapsin I pS9 antibody is directed against rat Synapsin I, which plays a key role in synaptic plasticity in brain. This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator of synapse formation. Thus, synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation. Serine 9 is the site on synapsin I that is phosphorylated by cAMP-dependent protein kinase and by calcium calmodulin kinase I. Phosphorylation of this site is thought to regulate synaptic vesicle function and neurite outgrowth. Anti-Synapsin I pS9 Antibody is ideal for investigators involved in Cell Signaling, Neuroscience, Signal Transduction research.
Gene Name: SYN1
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基因ID
- 24949
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NCBI登录号
- NP_001104252
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UniProt
- P09951
抗原
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