ITPR1 抗体 (C-Term)
Quick Overview for ITPR1 抗体 (C-Term) (ABIN6658135)
抗原
See all ITPR1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- C-Term
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Supplier Product No.
- 200-301-f77
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Supplier
- Rockland
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原理
- IP3 Receptor Antibody
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交叉反应 （详细）
- A BLAST analysis was used to suggest cross-reactivity with IP3 from Human, Mouse, and Rat based on 100 % homology with the immunizing sequence.
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纯化方法
- Anti-IP3 Antibody was purified by Protein G chromatography.
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过滤
- Sterile filtered
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免疫原
- IP3 Receptor Antibody was produced in mice by repeated immunizations raised against a fusion protein of the cytoplasmic carboxyl terminus region of rat type1 IP3R inositol 1,4,5-triphosphate receptor type 1, Itpr1.
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亚型
- IgG1
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anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) (AA 2411-2758) antibody
ITPR1 适用: 人, 大鼠, 小鼠 IHC, WB, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) antibodyITPR1 适用: 人 IHC, WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) (AA 1707-1966) antibodyITPR1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) (AA 2731-2749) antibodyITPR1 适用: 人, 大鼠, 小鼠, Cow IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) antibodyITPR1 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) (AA 1892-1911) antibodyITPR1 适用: 人, 大鼠, 小鼠, Cow, 猴 IHC, WB, IP, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) (pSer1764) antibodyITPR1 适用: 人 ELISA, IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) (pSer1756), (pSer1764) antibodyITPR1 适用: 人, 大鼠, 小鼠 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1) (AA 2470-2577) antibodyITPR1 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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Immunohistochemistry_Dilution: 0.1-1.0 μg/mL
IF_Microscopy_Dilution: 1.0-10 μg/mL
Western_Blot_Dilution: 1 μg/mL
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说明
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Anti-IP3 Antibody is tested for use in WB, IP, and IHC. Expect a band approximately ~300kDa on specific lysates. Does not recognize type 2 or type 3 IP3R's. Specific conditions for reactivity should be optimized by the end user.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 50 % (v/v) Glycerol
Preservative: 0.09 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))
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别名
- Itpr1
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背景
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Synonyms: IP3 Receptor, S24-18,Inositol 1,4,5-trisphosphate receptor type 1,IP3 receptor isoform 1, IP-3-R, IP3R1,Type 1 inositol 1,4,5-trisphosphate receptor, Insp3r
Background: Inositol 1,4,5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium release channel family, and is located in the endoplasmic reticulum. It functions as a Ca2+ release channel for intracellular stores of calcium ions. There are three types of IP3 receptors (IP3 receptor 1, 2 and 3) that require the second messenger inositol 1,4,5-triphosphate (IP3) for activation. Four individual receptor subunits, resulting in homo- or heterooligomerization of the receptor isoform, form a functional channel. Phosphorylation of IP3R1 at Ser1756 by cyclic- AMP-dependent protein kinase A (PKA) regulates the sensitivity of IP3R1 to IP3 and may thus be a mode of regulation for Ca2+ release. IP3R1 mediated calcium release appears to have an effect on the induction of long term depression (LTD) in Purkinje cells.
Gene Name: Itpr1
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基因ID
- 25262
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NCBI登录号
- NP_001007236
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UniProt
- P29994
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途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, Synaptic Membrane, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
抗原
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