MAPK14 抗体
Quick Overview for MAPK14 抗体 (ABIN6656051)
抗原
See all MAPK14 抗体适用
宿主
克隆类型
标记
应用范围
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Supplier Product No.
- 100-401-g26
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Supplier
- Rockland
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原理
- p38 Antibody
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交叉反应 （详细）
- A BLAST analysis was used to suggest cross-reactivity with p38 from Human, Monkey, Mouse, Rat, Bovine, Rabbit, Pig, Canine, Hamster, Chicken, Sheep, and Guinea pig based on 100 % homology with the immunizing sequence.
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纯化方法
- Anti-p38 Antibody was prepared from monospecific antiserum by delipidation and defibrination.
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过滤
- Sterile filtered
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免疫原
- p38 Antibody was produced from whole rabbit serum prepared by repeated immunizations raised against a 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH.
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亚型
- IgG
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anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (pThr180), (pTyr182) antibody
MAPK14 适用: 人, 小鼠, 大鼠, 小鸡, 山羊 WB, ELISA, IHC (p), FACS, IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (AA 299-360) antibodyMAPK14 适用: 人 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 8G4D11 unconjugated
anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (AA 141-240) antibodyMAPK14 适用: 人, 小鼠, 大鼠, 兔 WB, ELISA, IHC (p), ICC, FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (AA 19-279) antibodyMAPK14 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (AA 260-360) antibodyMAPK14 适用: 人 WB, ELISA, IP, IHC (p), PLA 宿主: 小鼠 Monoclonal 3D5 unconjugated
anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (AA 295-324), (C-Term) antibodyMAPK14 适用: 人 WB, IF, FACS 宿主: 兔 Polyclonal RB2723 unconjugated
anti-Mitogen-Activated Protein Kinase 14 (MAPK14) antibodyMAPK14 适用: 人, 小鼠, 大鼠, Pig WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (C-Term) antibodyMAPK14 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (AA 299-360) antibodyMAPK14 适用: 人, 小鼠 WB, IHC, ELISA, FACS, IF/ICC 宿主: 小鼠 Monoclonal unconjugated
anti-Mitogen-Activated Protein Kinase 14 (MAPK14) (AA 295-324) antibodyMAPK14 适用: 人 WB, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunoprecipitation_Dilution: 1:250
Immunohistochemistry_Dilution: User Optimized
Western_Blot_Dilution: 1:1000
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说明
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Anti-p38 Antibody has been tested in WB, IP, IF, and IHC. Expect a band approximately ~43kDa protein corresponding to the molecular mass of p38 on SDS PAGE immunoblots. Specific conditions for reactivity should be optimized by the end user.
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限制
- 仅限研究用
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状态
- Liquid
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- MAPK14 (Mitogen-Activated Protein Kinase 14 (MAPK14))
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别名
- p38
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背景
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Synonyms: CSAID Binding protein 1, CSBP1, CSBP2, EXIP, MAP kinase MXI2, MAPkinase p38alpha, MAPK14, p38 ALPHA, p38 MAP kinase, p38 mitogen activated protein kinase, RK, SAPK 2A, Stress activated protein kinase 2A, 39S ribosomal protein L23, mitochondrial, L23 mitochondrial-related protein
Background: The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, protein-serine/threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. This super family consists of stress activated protein kinases (SAPKs), extracellular signal-regulated kinases (ERKs), and p38 kinases, each of which forms a separate pathway. The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2α translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death. Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP. p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs. As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis and has also been implicated in cancer, CNS and diabetes.
Gene Name: MRPL23
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基因ID
- 1432
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NCBI登录号
- NP_001306
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UniProt
- Q16539
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途径
- MAPK Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Hepatitis C, Toll-Like Receptors Cascades, Autophagy, Thromboxane A2 Receptor Signaling, BCR Signaling, S100 Proteins
抗原
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