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GRK2 抗体 (C-Term)

This anti-GRK2 antibody is a 山羊 多克隆 antibody detecting GRK2 in WB, ELISA, IHC 和 FM. Suitable for 人.
Rockland
产品编号 ABIN6655845
Supplier Product No.: 600-101-mh5s
发货至: 中国

Quick Overview for GRK2 抗体 (C-Term) (ABIN6655845)

抗原

See all GRK2 (ADRBK1) 抗体
GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

适用

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宿主

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山羊

克隆类型

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多克隆

标记

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This GRK2 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Fluorescence Microscopy (FM)
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    C-Term

    Supplier Product No.

    600-101-mh5s

    Supplier

    Rockland

    原理

    GRK2 Antibody

    交叉反应 (详细)

    This affinity purified antibody is directed against human GRK2.

    纯化方法

    This product was affinity purified from monospecific antiserum by immunoaffinity purification.

    过滤

    Sterile filtered

    免疫原

    Anti-GRK2 antibody was prepared from whole goat serum produced by repeated immunizations with a synthetic peptide corresponding to a near C-terminal portion of human GRK2 conjugated to Keyhole Limpet Hemocyanin (KLH).

    亚型

    IgG
  • 应用备注

    ELISA_Dilution: 5 μg/mL

    Immunohistochemistry_Dilution: 1:1000

    IF_Microscopy_Dilution: 15 μg/mL

    Western_Blot_Dilution: 1:1000

    说明

    Anti-GRK2 Antibody has been tested in Western Blot and IHC. Expect a band at ~79.6kDa in western blot using appropriate lysates. Positive control used: Human high grade lymphoma tissue in Immunohistochemistry and THP-1 lysate in western blot.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative: 0.01 % (w/v) Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store vial at -20° C or below prior to opening. This vial contains a relatively low volume of reagent (25 μL). To minimize loss of volume dilute 1:10 by adding 225 μL of the buffer stated above directly to the vial. Recap, mix thoroughly and briefly centrifuge to collect the volume at the bottom of the vial. Use this intermediate dilution when calculating final dilutions as recommended below. Store the vial at -20°C or below after dilution. Avoid cycles of freezing and thawing.

    有效期

    12 months
  • 抗原

    GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))

    别名

    GRK2

    背景

    Synonyms: Goat Anti-G Protein-Coupled Receptor Kinase 2 Antibody, Goat Anti-GRK2 Antibody, Beta-ARK-1, ADRBK1, BARK1, G-Protein Coupled Receptor Kinase 2, Adrenergic, Beta, Receptor Kinase 1, Adrenergic Beta Receptor Kinase 1, Beta-Adrenergic Receptor Kinase 1, EC 2.7.11.15, BETA-ARK1, BARK

    Background: GRK2 (G Protein-Coupled Receptor Kinase 2) is a member of the G protein-coupled receptor kinase family of proteins. GRK2 Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. It is a key regulator of LPAR1 signaling. GRK2 competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. It desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner. And positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. Anti-GRK2 Antibody is useful for researchers interested in Neuroscience, Cytokines & Growth Factors, and Stem Cell Research.

    Gene Name: GRK2

    基因ID

    156

    NCBI登录号

    NP_001610

    UniProt

    P25098

    途径

    EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling
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