RIPK3 抗体 (C-Term)
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北京 101111
Quick Overview for RIPK3 抗体 (C-Term) (ABIN6655574)
抗原
See all RIPK3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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Supplier Product No.
- 600-401-i08
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Supplier
- Rockland
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原理
- Receptor-interacting serine-threonine kinase 3 Antibody
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交叉反应 （详细）
- A BLAST analysis was used to suggest cross-reactivity with Anti-Receptor-interacting serine-threonine kinase 3 from human and chimpanzee based on 100 % homology with the immunizing sequence.
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纯化方法
- Anti-Receptor-interacting serine-threonine kinase 3 Antibody was purified by affinity chromatography.
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免疫原
- Receptor-interacting serine-threonine kinase 3 Antibody was produced from whole rabbit serum prepared by repeated immunizations with a peptide corresponding to amino acids near the c-terminus of human Receptor-interacting serine/threonine-protein kinase 3.
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亚型
- IgG
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anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (N-Term) antibody
RIPK3 适用: 人, 小鼠, 大鼠, Cow, Pig, 马, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (AA 61-91) antibodyRIPK3 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (AA 16-239) antibodyRIPK3 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (AA 489-518) antibodyRIPK3 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) antibodyRIPK3 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (AA 1-217) antibodyRIPK3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (AA 1-518) antibodyRIPK3 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (AA 1-120) antibodyRIPK3 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (AA 168-217) antibodyRIPK3 适用: 人, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Receptor-Interacting serine-threonine Kinase 3 (RIPK3) (AA 61-91) antibodyRIPK3 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB8634 unconjugated
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应用备注
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Immunohistochemistry_Dilution: 10 μg/mL
Western_Blot_Dilution: 3-7 μg/mL
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说明
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Anti-Receptor-interacting serine-threonine kinase 3 antibody is tested for use in WB, ICC/IF, IHC, IHC-P, and IP. Expect a band approximately 56 kDa (isoform 1) and 27 kDa (isoform 2) on specific lysates. Specific conditions for reactivity should be optimized by the end user.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 0.05 % BSA
Preservative: 0.05 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- RIPK3 (Receptor-Interacting serine-threonine Kinase 3 (RIPK3))
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别名
- Receptor-interacting serine-threonine kinase 3
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背景
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Synonyms: RIP3, Receptor-interacting serine/threonine-protein kinase 3, 2.7.11.1, RIP-like protein kinase 3, Receptor-interacting protein 3
Background: Anti-Receptor-interacting serine-threonine kinase 3 antibody detects human RIP3. RIP3 is a novel member of RIP Ser/Thr kinase family. It is a potent inducer of apoptosis and is an important component of TNFR1 signaling complex. RIP3 consists of an N-terminal RIP-like-Kinase domain and a unique, non-homologous C-terminus responsible for caspase activation and apoptosis induction. RIP3 is expressed in multiple tissues including hematopoietic cells and plays a functional role in the regulation of apoptosis and NF-kB signaling. It is recruited to the TNFR1 signaling complex in a RIP-dependant manner where it induces apoptosis by activating caspases and/or inhibiting TNFR1-induced NF-kB activation. RIP3 negatively regulates the TLR3-Trif mediated NF-kB signaling pathway by competing with the binding of Trif to RIP1. The human RIP3 gene is localized in the chromosomal region 14q11.2. Anti-Receptor-interacting serine-threonine kinase 3 Antibody is ideal for investigators involved in apoptosis and NFkappaB research.
Gene Name: RIPK3
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基因ID
- 11035
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NCBI登录号
- NP_006862
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UniProt
- Q9Y572
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途径
- Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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