CD40 抗体 (FITC)
Quick Overview for CD40 抗体 (FITC) (ABIN6655465)
抗原
See all CD40 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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Supplier Product No.
- 200-302-n67
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Supplier
- Rockland
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原理
- CD40 Fluorescein Antibody
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交叉反应 (详细)
- Reactivity is observed against human CD40.
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纯化方法
- Fluorescein conjugated CD40 Monoclonal Antibody was purified from tissue culture supernatant via affinity chromatography and is directed against human CD40.
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过滤
- Sterile filtered
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免疫原
- Anti-CD40 Antibody (Monoclonal) was produced by repeated immunizations with CD40 antigen.
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亚型
- IgG1 kappa
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Labeling Ratio
- 4-6
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应用备注
- Optional[Neutralization_Dilution]: 5 uL/test/1x10e5 to 1x10e8 cells
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说明
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Anti-CD40 is tested for Flow Cytometry. Researchers should determine optimal titers for applications that are not stated.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: 0.2 % BSA (w/v)
Preservative: 0.09 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store vial at 4° C prior to opening. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. DO NOT FREEZE. This product is light sensitive.
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有效期
- 6 months
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- CD40
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别名
- CD40
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背景
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Synonyms: BP50, TNFRSF5, Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40
Background: CD40 is a 48 kD type I glycoprotein also known as BP50. It is a member of the TNFR superfamily primarily expressed on B cells, macrophages, follicular dendritic cells, endothelial cells, fibroblasts, and at low levels on plasma cells. CD40 has been reported to be involved in B cell differentiation, costimulation, isotype class-switching, and protection of B cells from apoptosis. Additionally, CD40 is important for T cell-B cell interactions. The ligand of CD40 is CD154 (CD40 ligand). The 5C3 antibody has been reported to promote B cell proliferation in the presence of anti-IgM, IL-4 or PMA, partially blocking CD40 binding to CD40L, and B cells rescue from apoptosis.
Gene Name: CD40
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基因ID
- 958
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NCBI登录号
- NP_001241
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UniProt
- P25942
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途径
- NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
抗原
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