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Cyclin E1 抗体 (AA 10-176)

This anti-Cyclin E1 antibody is a 小鼠 单克隆 antibody detecting Cyclin E1 in IHC (p). Suitable for 人.
产品编号 ABIN6654285
发货至: 中国

Quick Overview for Cyclin E1 抗体 (AA 10-176) (ABIN6654285)

抗原

See all Cyclin E1 (CCNE1) 抗体
Cyclin E1 (CCNE1)

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This Cyclin E1 antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

CCNE1-2460
  • 抗原表位

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    AA 10-176

    纯化方法

    Purified

    纯度

    Protein G affinity chromatography

    免疫原

    Recombinant human partial protein (within amino acids 10-176) was used as the immunogen for the Cyclin E1 antibody.

    亚型

    IgG
  • 应用备注

    Optimal dilution of the Cyclin E1 antibody should be determined by the researcher.

    1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT

    限制

    仅限研究用
  • 缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    4 °C,-20 °C

    储存方法

    Store the Cyclin E1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • 抗原

    Cyclin E1 (CCNE1)

    别名

    Cyclin E1 / CCNE1

    背景

    Cyclin E belongs to the highly conserved cyclin family, whose members exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclins function as regulators of CDK kinases. Cyclin E forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Cyclin E overexpression has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis.

    途径

    Cell Division Cycle, Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Mitotic G1-G1/S Phases
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