Ret Proto-Oncogene 抗体
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北京 101111
Quick Overview for Ret Proto-Oncogene 抗体 (ABIN659065)
抗原
See all Ret Proto-Oncogene (RET) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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免疫原
- This RET Monoclonal antibody was raised using purified His-tagged recombinant human RET.
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亚型
- IgM kappa
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应用备注
- IF: 1:10~50. WB: 1:1000. WB: 1:500~16000. IHC-P: 1:50~100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid freeze-thaw cycles.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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: "Prognostic and Predictive Values of Subcellular Localisation of RET in Renal Clear-Cell Carcinoma." in: Disease markers, Vol. 2016, pp. 6870470, (2016) (PubMed).
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: "Prognostic and Predictive Values of Subcellular Localisation of RET in Renal Clear-Cell Carcinoma." in: Disease markers, Vol. 2016, pp. 6870470, (2016) (PubMed).
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- Ret Proto-Oncogene (RET)
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别名
- RET
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背景
- This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.
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分子量
- 124319
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基因ID
- 5979
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NCBI登录号
- NP_065681, NP_066124
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UniProt
- P07949
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途径
- RTK signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
抗原
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