Dual Specificity Phosphatase 3 (DUSP3) (AA 136-185) 抗体
Our Local Distributor
北京 101111
Quick Overview for Dual Specificity Phosphatase 3 (DUSP3) (AA 136-185) 抗体 (ABIN6579411)
抗原
See all Dual Specificity Phosphatase 3 (DUSP3) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 136-185
-
原理
- VHR Antibody
-
特异性
- VHR Polyclonal Antibody detects endogenous levels of VHR protein.
-
纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
-
免疫原
- The antiserum was produced against synthesized peptide derived from the C-terminal region of human DUSP3. AA range:136-185
-
亚型
- IgG
-
-
-
-
应用备注
- WB 1:500 - 1:2000. IHC: 1:100-300 ELISA: 1:20000.. IF 1:50-200
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C/1 year
-
有效期
- 12 months
-
-
- Dual Specificity Phosphatase 3 (DUSP3)
-
别名
- DUSP3
-
背景
-
Synonyms: DUSP3, VHR, Dual specificity protein phosphatase 3, Dual specificity protein phosphatase VHR, Vaccinia H1-related phosphatase, VHR
Background: The protein encoded byThis gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast ca
Gene Name: DUSP3
Protein Name: Dual specificity protein phosphatase 3
-
分子量
- 20 kDa
-
基因ID
- 1845
-
UniProt
- P51452
-
途径
- Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
-