Growth Hormone Receptor 抗体 (AA 21-70)
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Quick Overview for Growth Hormone Receptor 抗体 (AA 21-70) (ABIN6579402)
抗原
See all Growth Hormone Receptor (GHR) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 21-70
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原理
- GHR Antibody
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特异性
- GHR Polyclonal Antibody detects endogenous levels of GHR protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- The antiserum was produced against synthesized peptide derived from the N-terminal region of human GHR. AA range:21-70
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亚型
- IgG
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应用备注
- WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- Growth Hormone Receptor (GHR)
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别名
- GHR
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背景
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Synonyms: GHR, Growth hormone receptor, GH receptor, Somatotropin receptor
Background: This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011],
Gene Name: GHR
Protein Name: Growth hormone receptor
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分子量
- '70 kDa
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基因ID
- 2690
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OMIM
- 135620
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UniProt
- P10912
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途径
- NF-kappaB Signaling, JAK/STAT Signaling, Response to Growth Hormone Stimulus
抗原
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