NCOR2 抗体 (AA 994-1005)
Quick Overview for NCOR2 抗体 (AA 994-1005) (ABIN190289)
抗原
See all NCOR2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 994-1005
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原理
- Anti-Smrt Mouse Monoclonal Antibody
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特异性
- This antibody recognizes human SMRT.
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交叉反应
- 人
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免疫原
- A KLH-conjugated synthetic peptide derived from human SMRT corresponding to aa 994-1005
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亚型
- IgG1
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anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (AA 670-900) antibody
NCOR2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (AA 2201-2525) antibodyNCOR2 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (AA 1-110) antibodyNCOR2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (AA 511-560) antibodyNCOR2 适用: 人, 小鼠, 大鼠, Pig, 斑马鱼 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (N-Term) antibodyNCOR2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (C-Term) antibodyNCOR2 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (AA 541-590) antibodyNCOR2 适用: 人, 小鼠, 大鼠, Pig, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (N-Term) antibodyNCOR2 适用: 人, 小鼠, 大鼠, Pig, Cow, 犬, 斑马鱼, Saccharomyces cerevisiae WB 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Co-Repressor 2 (NCOR2) (AA 511-560) antibodyNCOR2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunoblotting and
Immunoprecipitation: use at 1-5 μg/mL.
Positive control: HBL100 -
限制
- 仅限研究用
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状态
- Liquid
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溶解方式
- Dilute in PBS or medium which is identical to that used in the assay system.
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浓度
- Lot specific
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缓冲液
- 10 mM PBS, pH 7.4.
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储存条件
- -20 °C
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储存方法
- This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
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- NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))
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别名
- NCOR2 / SMRT
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背景
- Nuclear receptor corepressor 2,Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). {PubMed:18212045, PubMed:20812024, PubMed:23911289}.,SMRT (Silencing Mediator for Retinoid and Thyroid receptors) is a 168 kD nuclear protein. Nuclear hormone receptors are transcription factors regulated by ligand binding. In the absence of ligand, there is a physical interaction between the nuclear receptors that do not interact with Hsp90 and a family of corepressors which includes SMRT. SMRT helps target histone deacetylases and other components of a multiprotein repressor complex to the specific target promoter to silence gene transcription.,Nucleus.,N-CoR2, CTG repeat protein 26, SMAP270, Silencing mediator of retinoic acid and thyroid hormone receptor, SMRT, T3 receptor-associating factor, TRAC, Thyroid-, retinoic-acid-receptor-associated corepressor
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UniProt
- Q9Y618
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途径
- Notch Signaling, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha
抗原
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