CTLA4 抗体 (AA 50-78)
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北京 101111
Quick Overview for CTLA4 抗体 (AA 50-78) (ABIN654422)
抗原
See all CTLA4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 50-78
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This IDDM12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 50-78 amino acids of human IDDM12.
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亚型
- IgG
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应用备注
- WB: 1:2000. WB: 1:2000. IHC-P: 1:50~100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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- CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
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别名
- IDDM12
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背景
- CTLA4 is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.
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分子量
- 24656
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基因ID
- 1493
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NCBI登录号
- NP_001032720, NP_005205
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UniProt
- P16410
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途径
- Cancer Immune Checkpoints
抗原
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