MICA 抗体 (AA 68-97)
Quick Overview for MICA 抗体 (AA 68-97) (ABIN652566)
抗原
See all MICA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 68-97
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This MICA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 68-97 amino acids from the Central region of human MICA.
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亚型
- Ig Fraction
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应用备注
- IF: 1:25. IF: 1:25. WB: 1:2000. WB: 1:2000. WB: 1:2000. WB: 1:2000. WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 6 months
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-
Allele Specific Expression of MICA Variants in Human Fibroblasts Suggests a Pathogenic Mechanism." in: The open rheumatology journal, Vol. 9, pp. 60-4, (2015) (PubMed).
: "2-deoxy D-glucose prevents cell surface expression of NKG2D ligands through inhibition of N-linked glycosylation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 188, Issue 4, pp. 1847-55, (2012) (PubMed).
: "
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Allele Specific Expression of MICA Variants in Human Fibroblasts Suggests a Pathogenic Mechanism." in: The open rheumatology journal, Vol. 9, pp. 60-4, (2015) (PubMed).
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- MICA (MHC Class I Polypeptide-Related Sequence A (MICA))
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别名
- MICA
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背景
- MICA is the higly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells.
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分子量
- 42915
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基因ID
- 4276
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NCBI登录号
- NP_000238
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UniProt
- Q29983
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途径
- Activation of Innate immune Response, Transition Metal Ion Homeostasis, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
抗原
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