CD40 Ligand 抗体
Our Local Distributor
北京 101111
Quick Overview for CD40 Ligand 抗体 (ABIN636590)
抗原
See all CD40 Ligand (CD40LG) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
纯化方法
- Purified
-
免疫原
- CD40 L antibody was raised in goat using highly pure recombinant human sCD40 as the immunogen.
-
-
-
-
应用备注
- Optimal conditions should be determined byt he investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
浓度
- Lot specific
-
缓冲液
- Lyophilized from PBS, pH 7.2.
-
注意事项
-
Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use. -
储存条件
- 4 °C/-20 °C
-
储存方法
- Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.
-
-
- CD40 Ligand (CD40LG)
-
别名
- CD40L
-
背景
- CD40, a member of the TNF receptor family, is a cell surface protein expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells, and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40-Ligand is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to immunodeficiency with hyper-IgM, a disease characterized by failure to produce IgG, IgA and IgE. The human CD40L gene codes for a 261 amino acid type II transmembrane protein, which contains a 22 amino acid cytoplasmic domain, a 24 amino acid transmembrane domain, and a 215 amino acid extracellular domain.
-
分子量
- 16.3 kDa (predicted detection band MW)
-
途径
- NF-kappaB Signaling, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
抗原
-