MCM10 抗体 (Middle Region)
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北京 101111
Quick Overview for MCM10 抗体 (Middle Region) (ABIN634085)
抗原
See all MCM10 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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特异性
- MCM10 antibody was raised against the middle region of MCM10
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纯化方法
- Affinity purified
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免疫原
- MCM10 antibody was raised using the middle region of MCM10 corresponding to a region with amino acids PKLSALAEAKKLAAITKLRAKGQVLTKTNPNSIKKKQKDPQDILEVKERV
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应用备注
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WB: 1 µg/mL
Optimal conditions should be determined by the investigator. -
说明
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MCM10 Blocking Peptide, (ABIN5614695), is also available for use as a blocking control in assays to test for specificity of this MCM10 antibody
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Lyophilized powder. Add distilled water for a 1 mg/mL concentration of MCM10 antibody in PBS
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浓度
- Lot specific
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缓冲液
- PBS
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注意事项
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Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use. -
储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
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- MCM10 (Minichromosome Maintenance Deficient 10 (MCM10))
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别名
- MCM10
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背景
- This protein is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding.
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分子量
- 98 kDa (MW of target protein)
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途径
- Mitotic G1-G1/S Phases, DNA Replication
抗原
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