ube3a 抗体 (N-Term)
Quick Overview for ube3a 抗体 (N-Term) (ABIN633810)
抗原
See all ube3a 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- UBE3 A antibody was raised against the N terminal Of Ube3
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纯化方法
- Affinity purified
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免疫原
- UBE3 A antibody was raised using the N terminal Of Ube3 corresponding to a region with amino acids SLQAKDEDKDEDEKEKAACSAAAMEEDSEASSSRIGDSSQGDNNLQKLGP
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应用备注
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WB: 1 µg/mL
Optimal conditions should be determined by the investigator. -
说明
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UBE3A Blocking Peptide, (ABIN5616878), is also available for use as a blocking control in assays to test for specificity of this UBE3A antibody
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Lyophilized powder. Add distilled water for a 1 mg/mL concentration of UBE0 antibody in PBS
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浓度
- Lot specific
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缓冲液
- PBS
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注意事项
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Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use. -
储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
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- ube3a (Ubiquitin Protein Ligase E3A (ube3a))
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别名
- UBE3A
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背景
- UBE3A is an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53.
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分子量
- 101 kDa (MW of target protein)
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway
抗原
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