SMAD2 抗体
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- 抗原 See all SMAD2 抗体
- SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SMAD2 antibody is un-conjugated
- 应用范围
- 请咨询
- 原理
- Rabbit Anti-Smad2 (Ab-465) Antibody,
- Top Product
- Discover our top product SMAD2 Primary Antibody
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- 限制
- 仅限研究用
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- 储存条件
- 4 °C,-20 °C
- 储存方法
- 2-8°C (short-term), -20°C (long-term)
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- 抗原
- SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
- 别名
- Smad2 (SMAD2 产品)
- 背景
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Target Description: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Gene Symbol: SMAD2
- 基因ID
- 4087
- UniProt
- Q15796
- 途径
- Cell Division Cycle, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus
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