SUMO1 抗体
Quick Overview for SUMO1 抗体 (ABIN6297475)
抗原
See all SUMO1 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Mouse anti-Human/Rat SUMO-1 Antibody (SENP2) [Sodium Azide Free]
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特异性
- Predominantly nuclear with some cytoplasmic
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纯化方法
- Recombinant human protein was used as the immunogen for the SUMO-1 antibody.
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免疫原
- Recombinant human protein was used as the immunogen for the SUMO-1 antibody.
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应用备注
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Flow Cytometry: 0.5-1 μg/million cells in 0.1ml
Immunofluorescence: 0.5-1 μg/mL
Western blot: 0.5-1 μg/mL
Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1)
Prediluted format: incubate for 30 min at RT (2) -
限制
- 仅限研究用
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缓冲液
- In 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))
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别名
- Small ubiquitin-related modifier 1
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背景
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Target Description: This mAb is specific to SUMO-1 and shows no cross-reaction with either SUMO-2 or SUMO-3. The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2 and SUMO-3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1 protein localizes to the nuclear membrane.
Gene Symbol: SUMO1///SMT3C///SMT3H3///UBL1///OK///SW-cl.43
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基因ID
- 7341
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UniProt
- P63165
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途径
- M Phase, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, Ubiquitin Proteasome Pathway
抗原
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