EGFR 抗体
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北京 101111
Quick Overview for EGFR 抗体 (ABIN6296699)
抗原
See all EGFR 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Mouse anti-Human EGF Receptor Antibody [Sodium Azide Free]
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特异性
- Cell surface
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纯化方法
- Microsomes from A431 cells were used as the immunogen for this antibody.
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免疫原
- Microsomes from A431 cells were used as the immunogen for this antibody.
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应用备注
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Functional Activity (Inhibition): antibody blocks EGF receptor activation, inhibits A431 cell proliferation, arrests tumor growth in vivo, affinity purification
IP: 1-2 μg/500 μg protein lysate
FACS: 0.5-1 μg/million cells -
限制
- 仅限研究用
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缓冲液
- In 1X PBS ( pH 7.4), BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- EGFR (Epidermal Growth Factor Receptor (EGFR))
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别名
- Epidermal growth factor receptor
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背景
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Target Description: This antibody reacts with the extracellular domain of EGF receptor and blocks the EGF/TGFa induced activation. It also blocks tumor growth in vivo. It is excellent for purification of EGF receptor. < a href=../search_result.php?search_txt=egfr>EGFR is type I receptor tyrosine kinase with sequence homology to < a href=../search_result.php?search_txt=erbb2>ErbB2, -3 -4 or < a href=../search_result.php?search_txt=her2>HER2, -3 -4. It binds to Epidermal Growth Factor (EGF), < a href=../search_result.php?search_txt=TGFa>Transforming Growth Factor-a (TGFa), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin.
Gene Symbol: EGFR///ERBB///ERBB1///HER1
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基因ID
- 1956
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UniProt
- P00533
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途径
- NF-kappaB Signaling, RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteins
抗原
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