C4A 抗体
Quick Overview for C4A 抗体 (ABIN6296522)
抗原
See all C4A (C4a) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Mouse anti-Human C4d Antibody Complement 4d [Sodium Azide Free]
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特异性
- Intracytoplasmic vacuoles of endothelial cells, Secreted
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纯化方法
- Human protein was used as the immunogen for this C4d antibody.
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免疫原
- Human protein was used as the immunogen for this C4d antibody.
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anti-Complement Fragment C4a (C4a) antibody
C4a 适用: 人 IHC, ELISA, Coat, StM 宿主: 小鼠 Monoclonal C4D204 unconjugated
anti-Complement Fragment C4a (C4a) (AA 680-756) antibodyC4a 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Complement Fragment C4a (C4a) (AA 1027-1186) antibodyC4a 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Complement Fragment C4a (C4a) antibodyC4a 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Complement Fragment C4a (C4a) antibodyC4a 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Complement Fragment C4a (C4a) (AA 678-761) antibodyC4a 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Complement Fragment C4a (C4a) (AA 1220-1270) antibodyC4a 适用: 人, 大鼠, 猴 WB, IHC, ELISA, IP 宿主: 兔 Polyclonal unconjugated
anti-Complement Fragment C4a (C4a) antibody (CF®488A)C4a 适用: 人 IHC, ELISA, IF, Coat, StM 宿主: 小鼠 Monoclonal C4D204 CF®488A
anti-Complement Fragment C4a (C4a) (AA 1200-1446) antibodyC4a 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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IF: 1:50-1:100
IHC (FFPE): 1:200-1:400 for 30 minutes at RT (1)
Prediluted format: incubate for 30 min at RT (2),ELISA: 1-2 μg/mL, order the BSA-free format -
限制
- 仅限研究用
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缓冲液
- In 1X PBS ( pH 7.4), BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C
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储存方法
- 2-8°C
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- C4A (C4a) (Complement Fragment C4a (C4a))
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别名
- Complement C4-A
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背景
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Target Description: This antibody is specific to Complement 4d (C4d) and it reacts with the secreted as well as cell-bound protein. C4d is a degradation product of the activated complement factor C4b. Complement 4b is typically activated by binding of antibodies to specific target molecules. Following activation and degradation of the C4 Molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product C4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. C4d has been shown to be a significant predictor of transplant kidney graft survival. C4d antibody, combined with antibody to C3d, can be utilized as a tool for diagnosis of allograft rejection that may warrant a prompt and aggressive anti-rejection treatment.
Gene Symbol: C4A///CO4///CPAMD2///C4B///CO4///CPAMD3///C4B_2
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基因ID
- 720
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UniProt
- P0C0L4, P0C0L5
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途径
- Complement System
抗原
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