Cyclin A 抗体
Quick Overview for Cyclin A 抗体 (ABIN6296265)
抗原
See all Cyclin A (CCNA2) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Mouse anti-Human/Mouse/Cow/African Green Monkey/Mink (Mustela) Cyclin A2 Antibody [Sodium Azide Free]
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特异性
- Predominantly nuclear
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纯化方法
- Full length bovine protein was used as the immunogen for this CCNA2 antibody.
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免疫原
- Full length bovine protein was used as the immunogen for this CCNA2 antibody.
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应用备注
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FACS: 0.5-1 μg/million cells
IF: 1-2 μg/mL, -
限制
- 仅限研究用
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缓冲液
- In 1X PBS ( pH 7.4), BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- Cyclin A (CCNA2) (Cyclin A2 (CCNA2))
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别名
- Cyclin-A2
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背景
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Target Description: This antibody recognizes a protein of 50-55 kDa, which is identified as Cyclin A. Its epitope is located amino acids 144-148 of the human protein. Cyclins are regulatory subunits of the cyclin-dependent kinases (cdk 's) and they control transition at different specific phases of the cell cycle. The temporal expression of cyclins is tightly regulated and subsequently plays a critical role in controlling the enzymatic activity of cdk 's. These cyclin/cdk complexes are essential for passage through specific stages in the cell cycle. In mammalian somatic cells, Cyclin A is required for S-phase and passage through G2-phase. The D and E type cyclins regulate the passage of G1, while Cyclin B is a critical regulator of mitosis. Mutation or disruption of normal Cyclin A expression causes cells to arrest in G2-phase.
Gene Symbol: CCNA2///CCN1///CCNA
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基因ID
- 890
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UniProt
- P20248
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途径
- PI3K-Akt Signaling, Cell Division Cycle, AMPK Signaling, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Synthesis of DNA
抗原
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