CD3 epsilon 抗体
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北京 101111
Quick Overview for CD3 epsilon 抗体 (ABIN6296157)
抗原
See all CD3 epsilon (CD3E) 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Rabbit anti-Human/Mouse/Rat/Primate/Guinea Pig/Hamster/Horse/Mole Rat/Pig/Rabbit/Sheep/Cat/Chicken/Cow/Dog/Frog/Opossum/Elephant CD3e Antibody [Sodium Azide Free]
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特异性
- Cell surface and cytoplasmic
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纯化方法
- Amino acids ERPPPVPNPDYEP (156-168) were used as the immunogen for this CD3e antibody.
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免疫原
- Amino acids ERPPPVPNPDYEP (156-168) were used as the immunogen for this CD3e antibody.
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应用备注
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FACS: use the CD3e antibody at 0.5-1 μg/million cells
WB: 0.5-1.0 μg/mL
IP: 1-2 μg/500 μg protein lysate, -
限制
- 仅限研究用
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缓冲液
- In 1X PBS ( pH 7.4), BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- CD3 epsilon (CD3E)
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别名
- T-cell surface glycoprotein CD3 epsilon chain
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背景
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Target Description: This antibody recognizes the epsilon-chain of CD3 (CD3e), which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16-28 kDa. The CD3 complex is closely associated at the lymphocyte cell surface with the Tcell antigen receptor (TCR). Reportedly, CD3 complex is involved in signal transduction to the Tcell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and probably represents one of the earliest signs of commitment to the Tcell lineage. In cortical thymocytes, CD3 is predominantly intra-cytoplasmic. However, in medullary thymocytes, it appears on the Tcell surface. CD3 antigen is a highly specific marker for Tcells, and is present in majority of Tcell neoplasms.
Gene Symbol: CD3E///T3E
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基因ID
- 916
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UniProt
- P07766
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途径
- TCR Signaling, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway
抗原
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