TNFSF15 抗体
Quick Overview for TNFSF15 抗体 (ABIN6295967)
抗原
See all TNFSF15 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- Mouse anti-Human VEGI / TL1A Antibody [Sodium Azide Free]
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特异性
- Cytoplasmic, cell surface, secreted
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纯化方法
- A full length human recombinant protein was used as the immunogen for this TL1A antibody.
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免疫原
- A full length human recombinant protein was used as the immunogen for this TL1A antibody.
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应用备注
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FACS: 0.5-1 μg/10^6 cells
IF: 1-2 μg/mL
Western blot: 1-2 μg/mL
IHC (FFPE): 1-2 μg/mL -
限制
- 仅限研究用
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缓冲液
- In 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- TNFSF15 (Tumor Necrosis Factor (Ligand) Superfamily, Member 15 (TNFSF15))
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别名
- Tumor necrosis factor ligand superfamily member 15
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背景
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Target Description: TNF ligand-related molecule 1 is an anti-angiogenic cytokine that is also called Tumor necrosis factor superfamily, member 15 (TNFSF15) and Vascular endothelial growth inhibitor (VEGI/VEGI192A). This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Reduced expression of TL1A has been reported as a marker of poor prognosis in breast cancer.
Gene Symbol: TNFSF15///TL1///VEGI
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基因ID
- 9966
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UniProt
- O95150
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途径
- Positive Regulation of Endopeptidase Activity, Autophagy
抗原
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