JUP 抗体 (N-Term)
Quick Overview for JUP 抗体 (N-Term) (ABIN6295501)
抗原
See all JUP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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原理
- Mouse anti-Human/Mouse Gamma Catenin Antibody / Plakoglobin [Sodium Azide Free]
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特异性
- Cell surface, cytoplasmic, cell junctions
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纯化方法
- Recombinant full length human gamma Catenin fused to maltose binding protein was used as the immunogen for the Plakoglobin antibody. The epitope has been found to be in the N-terminal region.
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免疫原
- Recombinant full length human gamma Catenin fused to maltose binding protein was used as the immunogen for the Plakoglobin antibody. The epitope has been found to be in the N-terminal region.
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应用备注
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Immunofluorescence: 1-2 μg/mL
WB: 0.5-1 μg/mL
Immunoprecipitation: suitable -
限制
- 仅限研究用
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缓冲液
- In 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- JUP (Junction Plakoglobin (JUP))
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别名
- Junction plakoglobin
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背景
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Target Description: It recognizes a protein of 80-87 kDa, identified as gamma-Catenin or Plakoglobin. The catenins (alpha, beta, gamma and δ,) are ubiquitously expressed, cytoplasmic proteins that associate with E-cadherin at cellular junctions. Catenin/cadherin complexes play an important role in mediating cellular adhesion. alpha T-catenin, also referred to as VR22, is a 895-amino acid protein that is most abundantly expressed in cardio-myocytes and in the peritubular myoid cells of the testis. alpha T-catenin binds to alpha E-catenin as well as to beta-catenin, and it functions to inhibit Wnt signaling. CTNNA3, the gene that encodes for alpha-T-catenin, is located on chromosome 10, and mutations in this gene show a strong correlation to late-onset Alzheimer s disease (LOAD) as well as to dilated cardiomyopathy.
Gene Symbol: JUP///CTNNG///DP3
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基因ID
- 3728
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UniProt
- P14923
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途径
- Cell-Cell Junction Organization, Maintenance of Protein Location
抗原
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