我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

TGFB1 抗体 (C-Term)

Name: TGFB1 抗体 (C-Term)
SKU: ABIN6266431
Availability: OutOfStock

This anti-TGFB1 antibody is a 兔多克隆 antibody detecting TGFB1 in WB, IHC, ELISA, ICC 和 IF. Suitable for 人, 小鼠和大鼠. This Primary Antibody has been cited in 5+ publications.

Western blot analysis of extracts from HepG2 cells, using TGF beta Antibody. (TGFB1 抗体 (C-Term))

ABIN6267067 at 1/100 staining mouse gastric tissue sections by IHC-P. (TGFB1 抗体 (C-Term))

IHC

ABIN6267067 at 1/100 staining mouse spleen tissue sections by IHC-P. (TGFB1 抗体 (C-Term))

IHC

ABIN6267067 at 1/100 staining mouse brain tissue sections by IHC-P. (TGFB1 抗体 (C-Term))

11 images

(5 references)

产品编号 ABIN6266431

发货至: 中国

Quick Overview for TGFB1 抗体 (C-Term) (ABIN6266431)

抗原

See all TGFB1 抗体

TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This TGFB1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)

抗原表位
61

16

15

9

9

8

7

6

5

5

4

4

4

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term

特异性

TGF beta1 Antibody detects endogenous levels of total TGF beta1.

预测反应

Pig,Bovine,Horse,Sheep,Dog

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human TGF beta1, corresponding to a region within C-terminal amino acids.

亚型

IgG
anti-Transforming Growth Factor, beta 1 (TGFB1) (AA 279-390) antibody
TGFB1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Transforming Growth Factor, beta 1 (TGFB1) (AA 62-195) antibody
TGFB1 适用: 人 IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 7F6 unconjugated

anti-Transforming Growth Factor, beta 1 (TGFB1) (AA 351-390) antibody
TGFB1 适用: 人, 小鼠, 大鼠, 绵羊, 兔 WB, ELISA, FACS, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Transforming Growth Factor, beta 1 (TGFB1) (Middle Region) antibody
TGFB1 适用: 小鼠, 大鼠, Cow, Pig, 绵羊, 豚鼠, 犬, 马, 山羊 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Transforming Growth Factor, beta 1 (TGFB1) (AA 62-195) antibody
TGFB1 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal unconjugated

anti-Transforming Growth Factor, beta 1 (TGFB1) (AA 279-390) antibody
TGFB1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Transforming Growth Factor, beta 1 (TGFB1) (N-Term) antibody
TGFB1 适用: 人 WB, ELISA, FM 宿主: 兔 Polyclonal unconjugated

anti-Transforming Growth Factor, beta 1 (TGFB1) (C-Term) antibody
TGFB1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Transforming Growth Factor, beta 1 (TGFB1) (AA 279-390) antibody
TGFB1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal D11 unconjugated

anti-Transforming Growth Factor, beta 1 (TGFB1) antibody
TGFB1 适用: 人, 小鼠, 猴 WB, ELISA 宿主: 小鼠 Monoclonal unconjugated

应用备注

WB: 1:500-1:2000, IHC: 1:50-1:200, IF/ICC 1:200, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
Yan, Li, Fan, Du, Ma, Cheng, Li, Zhang, Yu, Wang, Tang, Zheng: "The roles of Toll-like receptor 4 in the pathogenesis of pathogen-associated biliary fibrosis caused by Clonorchis sinensis." in: Scientific reports, Vol. 7, Issue 1, pp. 3909, (2018) (PubMed).

Xia, Deng, Zhou, Shao, Yang, Sha, Zou: "Expression and significance of Sirt1 in renal allografts at the early stage of chronic renal allograft dysfunction." in: Transplant immunology, Vol. 48, pp. 18-25, (2018) (PubMed).

Hui, Dingjie, Yuan, Zhongqiu, Na, Mingjian, Yu, Guangyuan, Xuemin, Shifeng, Yucong, Fang, Summer, Hong: "Silicosis decreases bone mineral density in rats." in: Toxicology and applied pharmacology, Vol. 348, pp. 117-122, (2018) (PubMed).

Zhao, Wu, Chen, Ji, Zheng: "TGF-β1 and connexin-43 expression in neurogenic bladder from rats with sacral spinal cord injury." in: Neurourology and urodynamics, (2018) (PubMed).

Ai, Liu, Lu, Liang, Sun, Chen, Sun, Li, Liu, Zhang, Liu, Xiao, Jing, Sun, Zhou, Yang: "Phenytoin silver: a new nanocompound for promoting dermal wound healing via comprehensive pharmacological action." in: Theranostics, Vol. 7, Issue 2, pp. 425-435, (2017) (PubMed).
抗原

TGFB1 (Transforming Growth Factor, beta 1 (TGFB1))

别名

TGFB1

背景

Description: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (By similarity). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (PubMed:25310401). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus (PubMed:25893292). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (PubMed:25893292).
Gene: TGFB1

分子量

45kDa

基因ID

7040

UniProt

P01137

途径

EGFR Signaling Pathway, Dopaminergic Neurogenesis, Cellular Response to Molecule of Bacterial Origin, Glycosaminoglycan Metabolic Process, Regulation of Leukocyte Mediated Immunity, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Production of Molecular Mediator of Immune Response, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus, Autophagy, Cancer Immune Checkpoints