RAD50 抗体 (Internal Region)
Quick Overview for RAD50 抗体 (Internal Region) (ABIN6266312)
抗原
See all RAD50 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- RAD50 Antibody detects endogenous levels of total RAD50.
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预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human RAD50, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-RAD50 Homolog (S. Cerevisiae) (RAD50) antibody
RAD50 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-RAD50 Homolog (S. Cerevisiae) (RAD50) (AA 228-359) antibodyRAD50 适用: 人, 大鼠 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 3D2G10 unconjugated
anti-RAD50 Homolog (S. Cerevisiae) (RAD50) (AA 1-100) antibodyRAD50 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-RAD50 Homolog (S. Cerevisiae) (RAD50) (AA 228-359) antibodyRAD50 适用: 人 ELISA 宿主: 小鼠 Monoclonal 5A8E5 unconjugated
anti-RAD50 Homolog (S. Cerevisiae) (RAD50) (AA 1-234) antibodyRAD50 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-RAD50 Homolog (S. Cerevisiae) (RAD50) antibodyRAD50 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-RAD50 Homolog (S. Cerevisiae) (RAD50) (AA 817-872) antibodyRAD50 适用: 人, 小鼠 WB, ELISA, ICC, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-RAD50 Homolog (S. Cerevisiae) (RAD50) (AA 700-750) antibodyRAD50 适用: 人, 小鼠, Cow, 兔, 犬 IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-RAD50 Homolog (S. Cerevisiae) (RAD50) (AA 631-793) antibodyRAD50 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-RAD50 Homolog (S. Cerevisiae) (RAD50) (AA 400-595) antibodyRAD50 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:400, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- RAD50 (RAD50 Homolog (S. Cerevisiae) (RAD50))
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别名
- RAD50
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背景
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Description: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:11741547, PubMed:9590181, PubMed:9705271, PubMed:9651580). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).
Gene: RAD50
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分子量
- 154kDa
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基因ID
- 10111
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UniProt
- Q92878
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途径
- DNA Damage Repair, Protein targeting to Nucleus
抗原
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