UBD 抗体 (Internal Region)
Quick Overview for UBD 抗体 (Internal Region) (ABIN6265840)
抗原
See all UBD 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- UBD Antibody detects endogenous levels of total UBD.
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预测反应
- Pig,Bovine,Horse,Rabbit
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human UBD, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Ubiquitin D (UBD) (AA 1-155) antibody
UBD 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin D (UBD) (AA 120-153) antibodyUBD 适用: 小鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin D (UBD) (AA 1-165) antibodyUBD 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin D (UBD) antibodyUBD 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin D (UBD) (AA 1-165) antibodyUBD 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin D (UBD) (AA 1-165) antibodyUBD 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin D (UBD) (AA 1-165) antibodyUBD 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 7D8 unconjugated
anti-Ubiquitin D (UBD) (AA 1-165) antibodyUBD 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin D (UBD) (AA 27-40), (N-Term) antibodyUBD 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin D (UBD) (AA 120-153), (C-Term) antibodyUBD 适用: 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB11812 unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- UBD (Ubiquitin D (UBD))
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别名
- UBD
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背景
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Description: Ubiquitin-like protein modifier which can be covalently attached to target protein and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner. Probably functions as a survival factor. Conjugation ability activated by UBA6. Promotes the expression of the proteasome subunit beta type-9 (PSMB9/LMP2). Regulates TNF-alpha-induced and LPS-mediated activation of the central mediator of innate immunity NF-kappa-B by promoting TNF-alpha-mediated proteasomal degradation of ubiquitinated-I-kappa-B-alpha. Required for TNF-alpha-induced p65 nuclear translocation in renal tubular epithelial cells (RTECs). May be involved in dendritic cell (DC) maturation, the process by which immature dendritic cells differentiate into fully competent antigen-presenting cells that initiate T-cell responses. Mediates mitotic non-disjunction and chromosome instability, in long-term in vitro culture and cancers, by abbreviating mitotic phase and impairing the kinetochore localization of MAD2L1 during the prometaphase stage of the cell cycle. May be involved in the formation of aggresomes when proteasome is saturated or impaired. Mediates apoptosis in a caspase-dependent manner, especially in renal epithelium and tubular cells during renal diseases such as polycystic kidney disease and Human immunodeficiency virus (HIV)-associated nephropathy (HIVAN).
Gene: UBD
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分子量
- 18kDa
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基因ID
- 10537
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UniProt
- O15205
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途径
- Ubiquitin Proteasome Pathway
抗原
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