MSK2 抗体 (Internal Region)
Quick Overview for MSK2 抗体 (Internal Region) (ABIN6263396)
抗原
See all MSK2 (RPS6KA4) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- MSK2 Antibody detects endogenous levels of total MSK2.
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预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human MSK2, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) (AA 237-393) antibody
RPS6KA4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) (pThr568) antibodyRPS6KA4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) (AA 1-220) antibodyRPS6KA4 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) (AA 322-354) antibodyRPS6KA4 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) (Thr568) antibodyRPS6KA4 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) (pThr568) antibodyRPS6KA4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) (C-Term) antibodyRPS6KA4 适用: 人, Cow, 犬, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) antibodyRPS6KA4 适用: 人 DB 宿主: 小鼠 Monoclonal 2934C1a unconjugated
anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) (AA 531-580), (pThr568) antibodyRPS6KA4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ribosomal Protein S6 Kinase A4 (RPS6KA4) (AA 322-354), (C-Term) antibodyRPS6KA4 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB1020 unconjugated
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应用备注
- WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- MSK2 (RPS6KA4) (Ribosomal Protein S6 Kinase A4 (RPS6KA4))
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别名
- RPS6KA4
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背景
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Description: Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.
Gene: RPS6KA4
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分子量
- 85kDa
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基因ID
- 8986
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UniProt
- O75676
抗原
-
