LAMP2 抗体 (C-Term)
Quick Overview for LAMP2 抗体 (C-Term) (ABIN6262907)
抗原
See all LAMP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- LAMP2 Antibody detects endogenous levels of total LAMP2.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human LAMP2, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Lysosomal-Associated Membrane Protein 2 (LAMP2) (AA 191-362) antibody
LAMP2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 2 (LAMP2) (AA 29-168) antibodyLAMP2 适用: 人 IHC, FACS, ELISA 宿主: 小鼠 Monoclonal 6A10H10 unconjugated
anti-Lysosomal-Associated Membrane Protein 2 (LAMP2) (AA 29-168) antibodyLAMP2 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, ELISA 宿主: 小鼠 Monoclonal 8E2F2 unconjugated
anti-Lysosomal-Associated Membrane Protein 2 (LAMP2) (AA 301-411) antibodyLAMP2 适用: 人, 小鼠, 大鼠, Pig WB, FACS, ELISA, IHC (fro), IHC (p), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 2 (LAMP2) (AA 193-375) antibodyLAMP2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 2 (LAMP2) antibodyLAMP2 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 2 (LAMP2) antibodyLAMP2 适用: 人 WB, FACS, ICC, IHC (fro), IHC (p) 宿主: 小鼠 Monoclonal H4B4 unconjugated
anti-Lysosomal-Associated Membrane Protein 2 (LAMP2) antibodyKO Validated LAMP2 适用: 人 WB, ICC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 2 (LAMP2) (AA 54-268) antibodyLAMP2 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Lysosomal-Associated Membrane Protein 2 (LAMP2) (AA 30-127) antibodyLAMP2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2G10 unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))
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别名
- LAMP2
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背景
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Description: Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032). Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125). Plays a role in lysosomal protein degradation in response to starvation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation, antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820). Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).
Gene: LAMP2
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分子量
- 45kDa
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基因ID
- 3920
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UniProt
- P13473
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途径
- Autophagy
抗原
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