EPH Receptor A4 抗体 (Internal Region)
Quick Overview for EPH Receptor A4 抗体 (Internal Region) (ABIN6261563)
抗原
See all EPH Receptor A4 (EPHA4) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- EPHA4 Antibody detects endogenous levels of total EPHA4.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human EPHA4, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-EPH Receptor A4 (EPHA4) (AA 40-70), (N-Term) antibody
EPHA4 适用: 人 WB, IHC (p), IF, FACS 宿主: 兔 Polyclonal RB1587 unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 621-882) antibodyEPHA4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 345-545) antibodyEPHA4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 887-986) antibodyEPHA4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6H7 unconjugated
anti-EPH Receptor A4 (EPHA4) antibodyEPHA4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 531-630) antibodyEPHA4 适用: 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 383-417) antibodyEPHA4 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB50832 unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 887-986) antibodyEPHA4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 777-986) antibodyEPHA4 适用: 人 ELISA 宿主: 小鼠 Monoclonal 7D3D4 unconjugated
anti-EPH Receptor A4 (EPHA4) (AA 875-904), (C-Term) antibodyEPHA4 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB1590 unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- EPH Receptor A4 (EPHA4)
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别名
- EPHA4
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背景
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Description: Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium.
Gene: EPHA4
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分子量
- 110 kDa
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基因ID
- 2043
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UniProt
- P54764
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途径
- RTK signaling
抗原
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