CHMP4B 抗体 (N-Term)
Quick Overview for CHMP4B 抗体 (N-Term) (ABIN6260812)
抗原
See all CHMP4B 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- CHMP4B Antibody detects endogenous levels of total CHMP4B.
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预测反应
- Pig,Zebrafish,Bovine,Sheep,Rabbit,Dog,Chicken,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CHMP4B, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-Charged Multivesicular Body Protein 4B (CHMP4B) (AA 101-200) antibody
CHMP4B 适用: 人, 大鼠 ELISA, IF (cc), IF (p), IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 4B (CHMP4B) (AA 1-224) antibodyCHMP4B 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 4B (CHMP4B) antibodyCHMP4B 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 4B (CHMP4B) (AA 51-79), (N-Term) antibodyCHMP4B 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB24088 unconjugated
anti-Charged Multivesicular Body Protein 4B (CHMP4B) (AA 1-224) antibodyCHMP4B 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 4B (CHMP4B) antibodyCHMP4B 适用: 人, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 4B (CHMP4B) (Middle Region) antibodyCHMP4B 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 4B (CHMP4B) (AA 143-192) antibodyCHMP4B 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, Bat, 小鸡, 猴, Pig IHC, WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Charged Multivesicular Body Protein 4B (CHMP4B) (AA 71-120) antibodyCHMP4B 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼, Bat, 小鸡, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- CHMP4B (Charged Multivesicular Body Protein 4B (CHMP4B))
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别名
- CHMP4B
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背景
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Description: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released (PubMed:12860994, PubMed:18209100). The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). Plays a role in the endosomal sorting pathway. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4B filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
Gene: CHMP4B
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分子量
- 29-33 kDa
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基因ID
- 128866
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UniProt
- Q9H444
抗原
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