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BTRC 抗体 (N-Term)

Name: BTRC 抗体 (N-Term)
SKU: ABIN6260326
Availability: OutOfStock

This anti-BTRC antibody is a 兔多克隆 antibody detecting BTRC in WB, ELISA, IHC, IF 和 ICC. Suitable for 人, 小鼠和大鼠.

Western blot analysis of extracts from mouse brain, using BTRC Antibody. (BTRC 抗体 (N-Term))

ABIN6276797 at 1/100 staining Mouse liver tissue by IHC-P. (BTRC 抗体 (N-Term))

IHC

Western blot analysis of extracts of Kidney, using BTRC antibody. (BTRC 抗体 (N-Term))

3 images

产品编号 ABIN6260326

发货至: 中国

Quick Overview for BTRC 抗体 (N-Term) (ABIN6260326)

抗原

See all BTRC 抗体

BTRC (beta-Transducin Repeat Containing (BTRC))

适用

人, 小鼠, 大鼠

宿主

兔

克隆类型

多克隆

标记

This BTRC antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Discover our top product BTRC Primary Antibody

抗原表位
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N-Term

特异性

BTRC Antibody detects endogenous levels of total BTRC.

预测反应

Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human BTRC, corresponding to a region within N-terminal amino acids.

亚型

IgG
anti-beta-Transducin Repeat Containing (BTRC) (AA 24-151) antibody
BTRC 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 4C5D8 unconjugated

anti-beta-Transducin Repeat Containing (BTRC) (AA 50-340) antibody
BTRC 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-beta-Transducin Repeat Containing (BTRC) antibody
BTRC 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-beta-Transducin Repeat Containing (BTRC) (AA 397-448) antibody
BTRC 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-beta-Transducin Repeat Containing (BTRC) (AA 1-605) antibody
BTRC 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-beta-Transducin Repeat Containing (BTRC) (AA 52-354) antibody
BTRC 适用: 人 WB, IF, FACS 宿主: 小鼠 Monoclonal 2H2 unconjugated

anti-beta-Transducin Repeat Containing (BTRC) (AA 17-52), (N-Term) antibody
BTRC 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB16275 unconjugated

anti-beta-Transducin Repeat Containing (BTRC) antibody
BTRC 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated

anti-beta-Transducin Repeat Containing (BTRC) (AA 701-1000) antibody
BTRC 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-beta-Transducin Repeat Containing (BTRC) (AA 52-354) antibody
BTRC 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 1F10 unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
抗原

BTRC (beta-Transducin Repeat Containing (BTRC))

别名

BTRC

背景

Description: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins (PubMed:10066435, PubMed:10497169, PubMed:10644755, PubMed:10835356, PubMed:11238952, PubMed:11359933, PubMed:11994270, PubMed:12791267, PubMed:12902344, PubMed:14603323, PubMed:14681206, PubMed:14988407, PubMed:15448698, PubMed:15917222, PubMed:16371461, PubMed:25503564, PubMed:25704143, PubMed:9859996). SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (PubMed:12077367, PubMed:12820959). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1, ATF4, CDC25A, DLG1, FBXO5, PER1, SMAD3, SMAD4, SNAI1 and probably NFKB2 (PubMed:10835356, PubMed:11238952, PubMed:14681206, PubMed:14603323). SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:10066435, PubMed:10497169, PubMed:10644755). Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:10066435). SCF(BTRC) mediates the ubiquitination of CEP68, this is required for centriole separation during mitosis (PubMed:25704143, PubMed:25503564). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:15917222). May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3 (PubMed:16371461).
Gene: BTRC

分子量

69kDa

基因ID

8945

UniProt

Q9Y297

途径

Cell Division Cycle, Hedgehog Signaling