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- 抗原 See all BIRC3 抗体
- BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))
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抗原表位
- N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This BIRC3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- BIRC3 Antibody detects endogenous levels of total BIRC3.
- 预测反应
- Sheep
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human BIRC3, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product BIRC3 Primary Antibody
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anti-Baculoviral IAP Repeat Containing 3 (BIRC3) antibody
BIRC3 适用: 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat Containing 3 (BIRC3) (AA 1-180) antibodyBIRC3 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat Containing 3 (BIRC3) (AA 1-604) antibodyBIRC3 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat Containing 3 (BIRC3) (AA 1-604) antibodyBIRC3 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat Containing 3 (BIRC3) (N-Term) antibodyBIRC3 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat Containing 3 (BIRC3) (AA 59-88), (N-Term) antibodyBIRC3 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB34025 unconjugated
anti-Baculoviral IAP Repeat Containing 3 (BIRC3) (AA 76-245) antibodyBIRC3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat Containing 3 (BIRC3) (Internal Region) antibodyVerified BIRC3 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Baculoviral IAP Repeat Containing 3 (BIRC3) (AA 255-529) antibodyBIRC3 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 1D12 unconjugated
anti-Baculoviral IAP Repeat Containing 3 (BIRC3) (AA 100-200) antibodyBIRC3 适用: 人 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- BIRC3 (Baculoviral IAP Repeat Containing 3 (BIRC3))
- 别名
- BIRC3 (BIRC3 产品)
- 别名
- AIP1 antibody, API2 antibody, CIAP2 antibody, HAIP1 antibody, HIAP1 antibody, MALT2 antibody, MIHC antibody, RNF49 antibody, c-IAP2 antibody, Api1 antibody, Api2 antibody, IAP1 antibody, IAP2 antibody, MIHB antibody, Birc2 antibody, HIAP2 antibody, MIAP1 antibody, MIAP2 antibody, cIAP1 antibody, cIAP2 antibody, cIAP-1 antibody, cIAP-2 antibody, AW107670 antibody, BIRC2 antibody, baculoviral IAP repeat containing 3 antibody, baculoviral IAP repeat-containing 3 antibody, baculoviral IAP repeat-containing protein 3 antibody, inhibitor of apoptosis protein-2 antibody, BIRC3 antibody, Birc3 antibody, LOC100399118 antibody, OpmnVgp074 antibody
- 背景
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Description: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
Gene: BIRC3
- 分子量
- 72 kDa
- 基因ID
- 330
- UniProt
- Q13489
- 途径
- Apoptosis, Caspase Cascade in Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades
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