HMGB2 抗体 (Internal Region)
Quick Overview for HMGB2 抗体 (Internal Region) (ABIN6258843)
抗原
See all HMGB2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- HMGB2 Antibody detects endogenous levels of total HMGB2.
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预测反应
- Bovine,Horse,Sheep,Rabbit,Dog,Chicken
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human HMGB2, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-High Mobility Group Box 2 (HMGB2) (AA 1-195) antibody
HMGB2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3C7 unconjugated
anti-High Mobility Group Box 2 (HMGB2) antibodyHMGB2 适用: 人 WB, IHC, IF, IP, ChIP 宿主: 兔 Monoclonal unconjugated
anti-High Mobility Group Box 2 (HMGB2) (AA 1-195) antibodyHMGB2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3D2 unconjugated
anti-High Mobility Group Box 2 (HMGB2) (AA 1-195) antibodyHMGB2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal X1 unconjugated
anti-High Mobility Group Box 2 (HMGB2) (AA 1-196) antibodyHMGB2 适用: 人 WB, IF, IHC (p), EIA 宿主: 小鼠 Monoclonal 3D2 unconjugated
anti-High Mobility Group Box 2 (HMGB2) (AA 1-196) antibodyHMGB2 适用: 人 WB, ELISA, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3D2 unconjugated
anti-High Mobility Group Box 2 (HMGB2) (AA 1-195) antibodyHMGB2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F2 unconjugated
anti-High Mobility Group Box 2 (HMGB2) (C-Term) antibodyHMGB2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, Pig, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-High Mobility Group Box 2 (HMGB2) (AA 65-97), (N-Term) antibodyHMGB2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-High Mobility Group Box 2 (HMGB2) (C-Term) antibodyHMGB2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 豚鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- HMGB2 (High Mobility Group Box 2 (HMGB2))
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别名
- HMGB2
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背景
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Description: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:7797075, PubMed:11909973, PubMed:19522541, PubMed:18413230, PubMed:19965638, PubMed:20123072). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (By similarity). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (PubMed:19811285). Has antimicrobial activity in gastrointestinal epithelial tissues (PubMed:23877675). Involved in inflammatory response to antigenic stimulus coupled with proinflammatory activity (By similarity). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (By similarity). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity).
Gene: HMGB2
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分子量
- 27 kDa
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基因ID
- 3148
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UniProt
- P26583
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途径
- Cellular Response to Molecule of Bacterial Origin
抗原
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