MARK2 抗体 (Internal Region)
Quick Overview for MARK2 抗体 (Internal Region) (ABIN6258272)
抗原
See all MARK2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Internal Region
-
特异性
- MARK2 Antibody detects endogenous levels of total MARK2.
-
预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
-
纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
-
免疫原
- A synthesized peptide derived from human MARK2, corresponding to a region within the internal amino acids.
-
亚型
- IgG
-
-
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 401-500) antibody
MARK2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3B12 unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 600-630) antibodyMARK2 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 600-630), (C-Term) antibodyMARK2 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2527-2528 unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (N-Term) antibodyMARK2 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 373-594) antibodyMARK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) antibodyMARK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 1-755) antibodyMARK2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 401-500) antibodyMARK2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3C5 unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (N-Term) antibodyMARK2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-MAP/microtubule Affinity-Regulating Kinase 2 (MARK2) (AA 10-59) antibodyMARK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
-
有效期
- 12 months
-
-
- MARK2 (MAP/microtubule Affinity-Regulating Kinase 2 (MARK2))
-
别名
- MARK2
-
背景
-
Description: Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.
Gene: MARK2
-
分子量
- 85 kDa
-
基因ID
- 2011
-
UniProt
- Q7KZI7
-
途径
- SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
抗原
-
