MAPK12 抗体 (Internal Region)
Quick Overview for MAPK12 抗体 (Internal Region) (ABIN6258157)
抗原
See all MAPK12 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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特异性
- MAPK12 Antibody detects endogenous levels of total MAPK12.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human MAPK12, corresponding to a region within the internal amino acids.
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亚型
- IgG
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anti-Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 27-311) antibody
MAPK12 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 251-367) antibodyMAPK12 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2C1 unconjugated
anti-Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 1-367) antibodyMAPK12 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4F4-3D2 unconjugated
anti-Mitogen-Activated Protein Kinase 12 (MAPK12) antibodyMAPK12 适用: 人 WB, IF, FACS 宿主: 小鼠 Monoclonal 3D4 unconjugated
anti-Mitogen-Activated Protein Kinase 12 (MAPK12) antibodyMAPK12 适用: 人 WB, IF, FACS 宿主: 小鼠 Monoclonal 4C1 unconjugated
anti-Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 314-367) antibodyMAPK12 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 1-367) antibodyMAPK12 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 251-367) antibodyMAPK12 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1G4 unconjugated
anti-Mitogen-Activated Protein Kinase 12 (MAPK12) (AA 339-367) antibodyMAPK12 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB03195-03196 unconjugated
anti-Mitogen-Activated Protein Kinase 12 (MAPK12) (pThr183), (pTyr185) antibodyMAPK12 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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有效期
- 12 months
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- MAPK12 (Mitogen-Activated Protein Kinase 12 (MAPK12))
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别名
- MAPK12
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背景
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Description: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes, and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.
Gene: MAPK12
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分子量
- ?42 kDa
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基因ID
- 6300
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UniProt
- P53778
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途径
- MAPK Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Hepatitis C, BCR Signaling, S100 Proteins
抗原
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