CLK2 抗体 (N-Term)
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北京 101111
Quick Overview for CLK2 抗体 (N-Term) (ABIN6258007)
抗原
See all CLK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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特异性
- CLK2 Antibody detects endogenous levels of total CLK2.
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预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human CLK2, corresponding to a region within N-terminal amino acids.
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亚型
- IgG
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anti-CDC-Like Kinase 2 (CLK2) (N-Term) antibody
CLK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-CDC-Like Kinase 2 (CLK2) (AA 240-499) antibodyCLK2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-CDC-Like Kinase 2 (CLK2) (N-Term) antibodyCLK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-CDC-Like Kinase 2 (CLK2) (AA 1-498) antibodyCLK2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-CDC-Like Kinase 2 (CLK2) (AA 66-93), (N-Term) antibodyCLK2 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-CDC-Like Kinase 2 (CLK2) (AA 1-30), (N-Term) antibodyCLK2 适用: 人 WB 宿主: 兔 Polyclonal RB3205 unconjugated
anti-CDC-Like Kinase 2 (CLK2) (N-Term) antibodyCLK2 适用: 人, 猴 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
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有效期
- 12 months
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- CLK2 (CDC-Like Kinase 2 (CLK2))
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别名
- CLK2
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背景
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Description: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Gene: CLK2
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分子量
- 60 kDa
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基因ID
- 1196
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UniProt
- P49760
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途径
- Regulation of Carbohydrate Metabolic Process
抗原
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