MTA1 抗体 (Internal Region)
Quick Overview for MTA1 抗体 (Internal Region) (ABIN6257333)
抗原
See all MTA1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Internal Region
-
特异性
- MTA1 Antibody detects endogenous levels of total MTA1.
-
预测反应
- Pig,Bovine,Horse,Rabbit,Dog,Chicken
-
纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
-
免疫原
- A synthesized peptide derived from human MTA1, corresponding to a region within the internal amino acids.
-
亚型
- IgG
-
-
anti-Metastasis Associated 1 (MTA1) (AA 601-700) antibody
MTA1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4D11 unconjugated
anti-Metastasis Associated 1 (MTA1) (AA 601-700) antibodyMTA1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4D5 unconjugated
anti-Metastasis Associated 1 (MTA1) (AA 601-700) antibodyMTA1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1C3 unconjugated
anti-Metastasis Associated 1 (MTA1) (AA 541-715) antibodyMTA1 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 6B1E9 unconjugated
anti-Metastasis Associated 1 (MTA1) (AA 601-715) antibodyMTA1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IHC (fro), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Metastasis Associated 1 (MTA1) antibodyMTA1 适用: 人 IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Metastasis Associated 1 (MTA1) (AA 541-715) antibodyMTA1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 7G9C10 unconjugated
anti-Metastasis Associated 1 (MTA1) (Internal Region) antibodyVerified MTA1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Metastasis Associated 1 (MTA1) (AA 659-687), (C-Term) antibodyMTA1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB40949 unconjugated
anti-Metastasis Associated 1 (MTA1) (AA 1-255) antibodyMTA1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 mg/mL
-
缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
-
有效期
- 12 months
-
-
- MTA1 (Metastasis Associated 1 (MTA1))
-
别名
- MTA1
-
背景
-
Description: Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator. As a part of the histone-deacetylase multiprotein complex (NuRD), regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA. In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A. Acts as a transcriptional coactivator of BCAS3, PAX5 and SUMO2, independent of the NuRD complex. Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3. Regulates p53-dependent and -independent DNA repair processes following genotoxic stress. Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair. Plays an important role in tumorigenesis, tumor invasion, and metastasis. Involved in the epigenetic regulation of ESR1 expression in breast cancer in a TFAP2C, IFI16 and HDAC4/5/6-dependent manner. Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles. Positively regulates the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1. Regulates deacetylation of ARNTL/BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression. Isoform Short binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity).
Gene: MTA1
-
分子量
- 80 kDa
-
基因ID
- 9112
-
UniProt
- Q13330
-
途径
- Chromatin Binding
抗原
-
