MAPK13 抗体 (C-Term)
Quick Overview for MAPK13 抗体 (C-Term) (ABIN6256863)
抗原
See all MAPK13 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- MAPK13 Antibody detects endogenous levels of total MAPK13.
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预测反应
- Pig,Bovine,Sheep,Rabbit,Dog
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纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
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免疫原
- A synthesized peptide derived from human MAPK13, corresponding to a region within C-terminal amino acids.
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亚型
- IgG
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anti-Mitogen-Activated Protein Kinase 13 (MAPK13) (AA 251-365) antibody
MAPK13 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2D8 unconjugated
anti-Mitogen-Activated Protein Kinase 13 (MAPK13) (AA 1-365) antibodyMAPK13 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2C10-1C7 unconjugated
anti-Mitogen-Activated Protein Kinase 13 (MAPK13) (AA 251-365) antibodyMAPK13 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1E11 unconjugated
anti-Mitogen-Activated Protein Kinase 13 (MAPK13) (AA 1-365) antibodyMAPK13 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 13 (MAPK13) (AA 1-365) antibodyMAPK13 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 3H7 unconjugated
anti-Mitogen-Activated Protein Kinase 13 (MAPK13) (AA 251-365) antibodyMAPK13 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2B6 unconjugated
anti-Mitogen-Activated Protein Kinase 13 (MAPK13) antibodyMAPK13 适用: 人, 小鼠, 大鼠, 猴, 犬 WB, IF, IHC, IHC (p) 宿主: 小鼠 Monoclonal 12B2 unconjugated
anti-Mitogen-Activated Protein Kinase 13 (MAPK13) antibodyMAPK13 适用: 人, 小鼠, 大鼠, 猴, 犬 WB, IF 宿主: 小鼠 Monoclonal 2G1 unconjugated
anti-Mitogen-Activated Protein Kinase 13 (MAPK13) (AA 332-365), (C-Term) antibodyMAPK13 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase 13 (MAPK13) (AA 1-365) antibodyMAPK13 适用: 人 WB, ELISA, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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有效期
- 12 months
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- MAPK13 (Mitogen-Activated Protein Kinase 13 (MAPK13))
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别名
- MAPK13
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背景
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Description: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.
Gene: MAPK13
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分子量
- 42 kDa
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基因ID
- 5603
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UniProt
- O15264
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途径
- MAPK Pathway, Neurotrophin Signaling Pathway, Hepatitis C, BCR Signaling, S100 Proteins
抗原
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