SMN1 抗体
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- 抗原 See all SMN1 抗体
- SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This SMN1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP)
- 原理
- anti-Survival Motor Neuron Protein (human), mAb (7B10)
- 产品特性
- Monoclonal Antibody. Recognizes a sequence of up to 9 amino acids in the N-terminal domain of human SMN. Isotype: Mouse IgG1. Clone: 7B10. Applications: IP, WB. Liquid. In PBS. The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. It is expressed in a wide variety of tissues, including high levels in brain, kidney and liver, moderate levels in skeletal and cardiac muscle and low levels in fibroblasts and lymphocytes. Mutations in SMN cause spinal muscular atrophy 1 (SMA1). Spinal muscular atrophy is a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. The antibody was used extensively to purify and characterize the macromolecular SMN complex from cultured human cells. The antibody binds with high affinity and specificity to its epitope, which comprises a sequence of up to 9 amino acids in the N-terminal part of human SMN. It allows the native elution of bound antigen with an excess of the cognate peptide. Via addition of the 7B10 epitope (TagIt epitope) to other proteins this purification strategy can also be exploited for purification of these fusion proteins and RNA-protein complexes from cells lacking this epitope on endogenous proteins, such as cells derived from C. elegans and Drosophila.
- 纯化方法
- Protein A/G purified.
- 免疫原
- Recombinant human full-length survival motor neuron protein (SMN).
- 克隆位点
- 7B10
- 亚型
- IgG1
- Top Product
- Discover our top product SMN1 Primary Antibody
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anti-Survival of Motor Neuron 1, Telomeric (SMN1) antibody
SMN1 适用: 人, 猴 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 5H1 unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) antibodySMN1 适用: 人, 猴 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 2F1 unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (AA 80-150) antibodySMN1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (N-Term) antibodySMN1 适用: 人, 小鼠, 大鼠, 犬, Pig, 兔, 马, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (AA 3-194) antibodySMN1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) antibodySMN1 适用: 人, 小鼠, 非洲爪蟾 WB, ELISA, IP, IF, ICC, IHC (p), FACS 宿主: 小鼠 Monoclonal 2B1 unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (AA 1-140) antibodySMN1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) antibodySMN1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) antibodySMN1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (AA 2-294) antibodySMN1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Liquid. In PBS.
- 注意事项
- Avoid freeze/thaw cycles.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 1 year after receipt when stored at -20°C.
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- 抗原
- SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))
- 别名
- Survival Motor Neuron Protein (SMN1 产品)
- 别名
- SMN2 antibody, Smn antibody, SMN antibody, BCD541 antibody, GEMIN1 antibody, SMA antibody, SMA1 antibody, SMA2 antibody, SMA3 antibody, SMA4 antibody, SMA@ antibody, SMNT antibody, T-BCD541 antibody, TDRD16A antibody, AI849087 antibody, Gemin1 antibody, SMN1 antibody, QtsA-10002 antibody, fa12d01 antibody, smn antibody, wu:fa12d01 antibody, survival motor neuron protein antibody, survival of motor neuron 1, telomeric antibody, survival motor neuron 1 antibody, survival of motor neuron 2, centromeric antibody, survival motor neuron protein-like antibody, survival motor neuron antibody, LOC461829 antibody, Smn1 antibody, SMN1 antibody, SMN2 antibody, LOC100348318 antibody, SMN antibody, LOC100713418 antibody, LOC100065744 antibody, LOC102176643 antibody, smn1 antibody
- 背景
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Alternate Names/Synonyms: SMN, Gemin-1, Component of Gems 1, BCD541
Product Description: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. It is expressed in a wide variety of tissues, including high levels in brain, kidney and liver, moderate levels in skeletal and cardiac muscle and low levels in fibroblasts and lymphocytes. Mutations in SMN cause spinal muscular atrophy 1 (SMA1). Spinal muscular atrophy is a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. The antibody was used extensively to purify and characterize the macromolecular SMN complex from cultured human cells. The antibody binds with high affinity and specificity to its epitope, which comprises a sequence of up to 9 amino acids in the N-terminal part of human SMN. It allows the native elution of bound antigen with an excess of the cognate peptide. Via addition of the 7B10 epitope (TagIt epitope) to other proteins this purification strategy can also be exploited for purification of these fusion proteins and RNA-protein complexes from cells lacking this epitope on endogenous proteins, such as cells derived from C. elegans and Drosophila.
- UniProt
- Q16637
- 途径
- Ribonucleoprotein Complex Subunit Organization
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