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- 抗原 See all SMN1 抗体
- SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))
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抗原表位
- AA 3-194
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SMN1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- 交叉反应
- 人
- 纯化方法
- >95%, Protein G purified
- 免疫原
- Recombinant Human Survival motor neuron protein (3-194AA)
- 亚型
- IgG
- Top Product
- Discover our top product SMN1 Primary Antibody
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anti-Survival of Motor Neuron 1, Telomeric (SMN1) antibody
SMN1 适用: 人, 猴 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 5H1 unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) antibodySMN1 适用: 人, 猴 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 2F1 unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (AA 80-150) antibodySMN1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (N-Term) antibodySMN1 适用: 人, 小鼠, 大鼠, 犬, Pig, 兔, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) antibodySMN1 适用: 人, 小鼠, 非洲爪蟾 WB, ELISA, IP, IF, IHC (p), ICC, FACS 宿主: 小鼠 Monoclonal 2B1 unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (AA 1-140) antibodySMN1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) antibodySMN1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) antibodySMN1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (AA 2-294) antibodySMN1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (AA 45-94) antibodySMN1 适用: 人, 小鼠, 猴, 犬 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4 - 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))
- 别名
- SMN1 (SMN1 产品)
- 别名
- SMN2 antibody, Smn antibody, SMN antibody, BCD541 antibody, GEMIN1 antibody, SMA antibody, SMA1 antibody, SMA2 antibody, SMA3 antibody, SMA4 antibody, SMA@ antibody, SMNT antibody, T-BCD541 antibody, TDRD16A antibody, AI849087 antibody, Gemin1 antibody, SMN1 antibody, QtsA-10002 antibody, fa12d01 antibody, smn antibody, wu:fa12d01 antibody, survival motor neuron protein antibody, survival of motor neuron 1, telomeric antibody, survival motor neuron 1 antibody, survival of motor neuron 2, centromeric antibody, survival motor neuron protein-like antibody, survival motor neuron antibody, LOC461829 antibody, Smn1 antibody, SMN1 antibody, SMN2 antibody, LOC100348318 antibody, SMN antibody, LOC100713418 antibody, LOC100065744 antibody, LOC102176643 antibody, smn1 antibody
- 背景
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Background: The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. Also required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs).
Aliases: BCD541 antibody, Component of gems 1 antibody, Gemin 1 antibody, Gemin-1 antibody, OTTHUMP00000125198 antibody, OTTHUMP00000223567 antibody, OTTHUMP00000223568 antibody, OTTHUMP00000224066 antibody, OTTHUMP00000226924 antibody, SMA 1 antibody, SMA 2 antibody, SMA 3 antibody, SMA 4 antibody, SMA antibody, SMA@ antibody, SMA1 antibody, SMA2 antibody, SMA3 antibody, SMA4 antibody, SMN antibody, SMN_HUMAN antibody, SMN1 antibody, SMN2 antibody, SMNT antibody, Survival motor neuron protein antibody, Survival of motor neuron 1, telomeric antibody, T-BCD541 antibody
- UniProt
- Q16637
- 途径
- Ribonucleoprotein Complex Subunit Organization
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