SMN1 抗体 (N-Term)
Our Local Distributor
北京 101111
Quick Overview for SMN1 抗体 (N-Term) (ABIN3043933)
抗原
See all SMN1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- N-Term
-
原理
- Anti-SMN1/2 Antibody
-
序列
- RRGTGQSDDS DIWDDTALIK AYDKAVASFK H
-
特异性
- No cross reactivity with other proteins.
-
交叉反应 （详细）
- No cross-reactivity with other proteins.
-
预测反应
- identical to the related mouse,rat sequences.
-
产品特性
- Anti-SMN1/2 Antibody. Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human SMN1/2, identical to the related mouse and rat sequences.
-
亚型
- IgG
-
-
anti-Survival of Motor Neuron 1, Telomeric (SMN1) antibody
SMN1 适用: 人, 猴 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 5H1 unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) antibodySMN1 适用: 人, 猴 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 2F1 unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (AA 80-150) antibodySMN1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (N-Term) antibodySMN1 适用: 人, 小鼠, 大鼠 WB, IHC, ICC 宿主: 小鼠 Monoclonal 2B10 unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (AA 2-294) antibodySMN1 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (AA 1-140) antibodySMN1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) (AA 3-194) antibodySMN1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) antibodySMN1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Survival of Motor Neuron 1, Telomeric (SMN1) antibodyKO Validated SMN1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB1840 unconjugated Recombinant Antibody
anti-Survival of Motor Neuron 1, Telomeric (SMN1) antibodySMN1 适用: 人, 小鼠, 非洲爪蟾 WB, ELISA, IP, IF, ICC, IHC (p), FACS 宿主: 小鼠 Monoclonal 2B1 unconjugated
-
-
应用备注
- Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human
-
说明
-
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg Sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
-
-
- SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))
-
别名
- SMN1
-
背景
-
Background: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. However, mutations in this gene, the telomeric copy, are associated with spinal muscular atrophy, mutations in the centromeric copy do not lead to disease. The centromeric copy may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Multiple transcript variants encoding distinct isoforms have been described.
Gene Full Name: survival of motor neuron 1, telomeric
Sequence Similarities: Belongs to the SMN family.
-
分子量
- 32 kDa
-
基因ID
- 6606
-
UniProt
- Q16637
-
途径
- Ribonucleoprotein Complex Subunit Organization
抗原
-
