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JUP 抗体

This anti-JUP antibody is a 小鼠 单克隆 antibody detecting JUP in WB, IF 和 IP. Suitable for 人, 小鼠, 大鼠, 小鸡, Cow, 犬 和 Cat.
产品编号 ABIN6252060
发货至: 中国

Quick Overview for JUP 抗体 (ABIN6252060)

抗原

See all JUP 抗体
JUP (Junction Plakoglobin (JUP))

适用

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人, 小鼠, 大鼠, 小鸡, Cow, 犬, Cat

宿主

  • 102
  • 70
  • 2
  • 1
小鼠

克隆类型

  • 92
  • 83
单克隆

标记

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This JUP antibody is un-conjugated

应用范围

  • 113
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Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

克隆位点

15F11
  • 纯化方法

    Protein G affinity chromatography

    免疫原

    Recombinant full length chicken gamma Catenin was used as the immunogen for the Plakoglobin antibody.

    亚型

    IgG1 kappa
  • 应用备注

    Immunofluorescence: 1-2 μg/mL

    WB: 0.5-1 μg/mL

    Immunoprecipitation: suitable

    The stated application concentrations are suggested starting amounts. Titration of the Plakoglobin antibody may be required due to differences in protocols and secondary/substrate sensitivity.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    PBS with 0.1 mg/mL BSA and 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot and Store at -20C. Avoid freez-thaw cycles.
  • 抗原

    JUP (Junction Plakoglobin (JUP))

    别名

    Gamma Catenin

    背景

    Plakoglobin, or gamma Catenin, is a common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of Plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity). [UniProt]

    基因ID

    3728

    UniProt

    P14923

    途径

    Cell-Cell Junction Organization, Maintenance of Protein Location
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