S100A8 抗体 (N-Term)
Our Local Distributor
北京 101111
Quick Overview for S100A8 抗体 (N-Term) (ABIN6251942)
抗原
See all S100A8 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- N-Term
-
纯化方法
- Protein G affinity chromatography
-
免疫原
- A recombinant protein fragment from the N-terminal region of human S100A8 was used as the immunogen for this antibody.
-
亚型
- IgG1 kappa
-
-
-
-
应用备注
-
Western blot: 2-4 μg/mL
Provided assay concentrations are suggestions only, S100A8 antibody titration may be required for optimal results. -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.5 mg/mL
-
缓冲液
- PBS with 0.1 mg/mL BSA and 0.05 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Aliquot and Store at -20C. Avoid freez-thaw cycles.
-
-
- S100A8 (S100 Calcium Binding Protein A8 (S100A8))
-
别名
- S100A8
-
背景
- The S100 family of proteins are found in vertebrates and are characterized by two calcium-binding sites that have a helix-loop-helix conformation. The family of 24 is divided into three subgroups based on function: those with intracellular, intracellular plus extracellular, and extracellular regulatory effects. The calcium-binding protein S100A8, also called MRP8 or Myeloid-related protein 8, and Calgranulin A, forms a heterodimer with S100A9, called Calprotectin. The heterodimer is expressed by granulocytes, monocytes, and early differentiation states of macrophages, and is known to be an important pro-inflammatory mediator in acute and chronic inflammation. S100A8 and 9 are DAMPs, or Damage-associated molecular pattern molecules, and are able to activate receptors of the innate immune system, one being TLR4.
-
基因ID
- 6279
-
UniProt
- P05109
-
途径
- Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, S100 Proteins
抗原
-