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EZH2 抗体 (AA 410-440)

Name: EZH2 抗体 (AA 410-440)
SKU: ABIN6244310
Availability: OutOfStock

This anti-EZH2 antibody is a 兔多克隆 antibody detecting EZH2 in WB 和 IHC (p). Suitable for 人和小鼠. This Primary Antibody has been cited in 4+ publications.

Anti-EZH2 Antibody at 1:1000 dilution + C6 whole cell lysates Lysates/proteins at 20 μg per lane. (EZH2 抗体 (AA 410-440))

Formalin-fixed and paraffin-embedded human Testis tissue reacted with EZH2 Antibody (Center) (ABIN6244310 and ABIN6578917) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. (EZH2 抗体 (AA 410-440))

IHC (p)

The anti-EZH2 Ctr Pab (ABIN6244310 and ABIN6578917) is used in Western blot to detect EZH2 in mouse kidney tissue lysate. (EZH2 抗体 (AA 410-440))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (EZH2 抗体 (AA 410-440))

IHC (p)

4 images

(4 references)

产品编号 ABIN6244310

发货至: 中国

Quick Overview for EZH2 抗体 (AA 410-440) (ABIN6244310)

抗原

See all EZH2 抗体

EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

适用

人, 小鼠

宿主

兔

克隆类型

多克隆

标记

This EZH2 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB2921

Discover our top product EZH2 Primary Antibody

抗原表位
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AA 410-440

预测反应

X, Pr

纯化方法

This antibody is purified through a protein A column, followed by peptide affinity purification.

免疫原

This EZH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from 410-440aa of human EZH2.

亚型

IgG
anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 51-285) antibody
EZH2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-194) antibody
EZH2 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 6G4F4 unconjugated

anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-296), (N-Term) antibody
EZH2 适用: 人, 小鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB23144 unconjugated

anti-Enhancer of Zeste Homolog 2 (EZH2) antibody
EZH2 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 144CT2-1-1-5 unconjugated

anti-Enhancer of Zeste Homolog 2 (EZH2) antibody
EZH2 适用: 人, 小鼠 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Enhancer of Zeste Homolog 2 (EZH2) antibody
EZH2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Enhancer of Zeste Homolog 2 (EZH2) antibody
EZH2 适用: 人 WB 宿主: 小鼠 Monoclonal EZH2-2536 unconjugated

anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-250) antibody
EZH2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Enhancer of Zeste Homolog 2 (EZH2) (Internal Region) antibody
EZH2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Enhancer of Zeste Homolog 2 (EZH2) (AA 1-110) antibody
EZH2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C3 unconjugated

应用备注

WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Pan, Wang, Zhu, Xing, Cui, Li, Yu, Wang, Zhu, Ye, Wu, Wang, Lu: "STAT3 signaling drives EZH2 transcriptional activation and mediates poor prognosis in gastric cancer." in: Molecular cancer, Vol. 15, Issue 1, pp. 79, (2017) (PubMed).

Lin, Zheng, Tu, Wang, Liu, Lu, Xu, Yuan: "MicroRNA-144 suppresses tumorigenesis and tumor progression of astrocytoma by targeting EZH2." in: Human pathology, Vol. 46, Issue 7, pp. 971-80, (2015) (PubMed).

Eskander, Ji, Huynh, Wardeh, Randall, Hoang: "Inhibition of enhancer of zeste homolog 2 (EZH2) expression is associated with decreased tumor cell proliferation, migration, and invasion in endometrial cancer cell lines." in: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, Vol. 23, Issue 6, pp. 997-1005, (2014) (PubMed).

Zhou, Flesken-Nikitin, Corney, Wang, Goodrich, Roy-Burman, Nikitin: "Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer." in: Cancer research, Vol. 66, Issue 16, pp. 7889-98, (2007) (PubMed).
抗原

EZH2 (Enhancer of Zeste Homolog 2 (EZH2))

别名

EZH2

背景

EZH2, SUZ12, and EED form a complex that methylates nucleosomal histone H3 at Lys27. EZH2 contains a SET domain, a signature motif for all known histone lysine methyltransferases except the H3-K79 methyltransferase DOT1, and is therefore likely to be the catalytic subunit. Consequently, EZH2 is thought to regulate gene expression by controlling chromatin structure. Several lines of evidence suggested a critical role for the EZH2 protein during normal and perturbed development of the hematopoietic and central nervous systems. The EZH2 protein has been shown to associate with the VAV1 protooncoprotein and with the XNP protein, the product of a gene associated with mental retardation. Additionally, due to mapping of EZH2 to the 7q35-q36 chromosomal region associated with myeloid disorders, this protein is suggested to participate in the genetic events triggering myeloid leukemia.

分子量

85363

NCBI登录号

NP_001190176, NP_001190177, NP_001190178, NP_004447, NP_694543

UniProt

Q15910

途径

Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation