SOS1 抗体 (AA 934-962)
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Quick Overview for SOS1 抗体 (AA 934-962) (ABIN6244011)
抗原
See all SOS1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 934-962
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This SOS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 934-962 amino acids from the Central region of human SOS1.
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亚型
- Ig Fraction
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anti-Son of Sevenless Homolog 1 (SOS1) (AA 1140-1281) antibody
SOS1 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) (AA 313-420) antibodySOS1 适用: 人 ELISA, PLA 宿主: 小鼠 Monoclonal 4C1 unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) antibodySOS1 适用: 人, 小鼠 WB, ELISA, IF 宿主: 小鼠 Monoclonal SOS-01 unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) antibodySOS1 适用: 人, 小鼠 WB, IF, EIA 宿主: 小鼠 Monoclonal SOS-1 unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) (AA 1034-1333) antibodySOS1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) (AA 313-420) antibodySOS1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) (AA 353-402) antibodySOS1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:2000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- SOS1 (Son of Sevenless Homolog 1 (SOS1))
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别名
- SOS1
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背景
- Son of Sevenless 1 protein is an activator of ras proteins by stimulating the exchange of GDP for GTP on ras. Murine Son of Sevenless proteins have been shown to form a complex with activated EGF receptor, coupling tyrosine kinases to ras proteins. The SOS gene was originally isolated in Drosophila. Two mammalian homologues (mSOS1 and mSOS2) have been isolated from a mouse cDNA library and are expressed in a variety of mouse embryo and adult tissues. Human SOS1 and SOS2 homologs have also been isolated. The two mouse homologs are approximately 70 % identical in composition. The mammalian SOS1 protein has a highly specific guanine nucleotide exchange activity towards p21ras. In epidermal growth factor stimulated cells, SOS1 interacts with SH3 domains of GRB2 and binds via SH2 domain to tyrosine 1068 of activated Epidermal Growth Factor receptor.
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分子量
- 152464
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NCBI登录号
- NP_005624
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UniProt
- Q07889
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途径
- RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
抗原
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